Department of Urology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
Int J Urol. 2010 Feb;17(2):125-38. doi: 10.1111/j.1442-2042.2009.02437.x. Epub 2009 Dec 16.
With the established effectiveness of diverse treatments for localized prostate cancer, the identification of the physical and psychological consequences of the disease and its various treatments has become critical. In the present review, we aim to familiarize the reader with the methodologies of health-related quality of life (HRQOL) research and to review the recent literature on HRQOL outcomes in patients with localized prostate cancer. Studies have shown that prostate cancer and its treatment affect both disease-specific HRQOL (i.e. urinary, sexual, and bowel function) as well as general HRQOL (i.e. energy/vitality and performance in physical and social roles). However, these effects appear to differ according to the type of treatment, stage of disease, age of the subjects, time after treatment, and, more importantly, race or ethnicity. By including HRQOL in clinical decision-making, we can help our patients make more informed treatment choices for localized prostate cancer.
随着针对局限性前列腺癌的各种治疗方法的疗效得到确立，确定疾病及其各种治疗方法的身体和心理后果变得至关重要。在本综述中，我们旨在使读者熟悉健康相关生活质量 (HRQOL) 研究的方法，并回顾有关局限性前列腺癌患者 HRQOL 结局的最新文献。研究表明，前列腺癌及其治疗既会影响疾病特异性 HRQOL（即尿、性和肠道功能），也会影响一般 HRQOL（即能量/活力以及身体和社会角色方面的表现）。然而，这些影响似乎因治疗类型、疾病分期、受试者年龄、治疗后时间以及更重要的种族或民族而异。通过将 HRQOL 纳入临床决策，我们可以帮助患者对局限性前列腺癌做出更明智的治疗选择。
