Department of Orthopedics and Trauma, Peking University People's Hospital, Beijing 100044, China.
Key Laboratory of Trauma and Neural Regeneration, Ministry of Education, Beijing 100044, China.
Int J Mol Sci. 2023 Aug 19;24(16):12956. doi: 10.3390/ijms241612956.
Peripheral nerve injuries are common neurological disorders, and the available treatment options, such as conservative management and surgical repair, often yield limited results. However, there is growing interest in the potential of using chitosan-based biopolymers as a novel therapeutic approach to treating these injuries. Chitosan-based biopolymers possess unique characteristics, including biocompatibility, biodegradability, and the ability to stimulate cell proliferation, making them highly suitable for repairing nerve defects and promoting nerve regeneration and functional recovery. Furthermore, these biopolymers can be utilized in drug delivery systems to control the release of therapeutic agents and facilitate the growth of nerve cells. This comprehensive review focuses on the latest advancements in utilizing chitosan-based biopolymers for peripheral nerve regeneration. By harnessing the potential of chitosan-based biopolymers, we can pave the way for innovative treatment strategies that significantly improve the outcomes of peripheral nerve injury repair, offering renewed hope and better prospects for patients in need.
周围神经损伤是常见的神经疾病,现有的治疗选择,如保守治疗和手术修复,往往效果有限。然而,人们越来越关注壳聚糖基生物聚合物作为治疗这些损伤的新治疗方法的潜力。壳聚糖基生物聚合物具有独特的特性,包括生物相容性、生物降解性和刺激细胞增殖的能力,使其非常适合修复神经缺陷和促进神经再生和功能恢复。此外,这些生物聚合物可用于药物输送系统,以控制治疗剂的释放并促进神经细胞的生长。本综述重点介绍了利用壳聚糖基生物聚合物促进周围神经再生的最新进展。通过利用壳聚糖基生物聚合物的潜力,我们可以为创新的治疗策略铺平道路,显著改善周围神经损伤修复的结果,为有需要的患者带来新的希望和更好的前景。