Division of Hematology/Oncology, Department of Medicine, Chao Family Comprehensive Cancer Center, University of California Irvine Medical Center, Orange, California 92868-3298, USA.
J Thorac Oncol. 2010 Feb;5(2):158-68. doi: 10.1097/JTO.0b013e3181c8cc62.
We previously reported that Asian ethnicity is a favorable prognostic factor for overall survival (OS) in non-small cell lung cancer (NSCLC) patients independent of smoking status. However, Asian ethnicity represents a diverse and heterogeneous population. In this report, we compared the clinicopathologic characteristics of Asian American NSCLC patient subgroups by smoking status.
Clinicopathologic characteristics of the five major Asian American NSCLC patient subgroups diagnosed between 1991 and 2005 from three Southern California counties were analyzed. Prognostic factors for OS were evaluated by Cox multivariate analysis.
One thousand one hundred twenty-four NSCLC patients were analyzed: Filipino American (37.0%), Vietnamese American (32.8%), Japanese American (11.8%), Chinese American (11.7%), and Korean American (6.7%). A total of 25.7% of these patients were never smokers. With the exception of Japanese American, most of Asian American were native born. Median age of never smokers was marginally younger than ever smokers (66 years versus 68 years, respectively, p = 0.0507). The proportion of never smokers who were women was 72.7% and ranged from the lowest among Korean American women (66.7%) to the highest among Japanese American women (84.2%). Among female patients, Vietnamese American patients had the highest proportion of being never smokers (65.5%). Significantly more never smokers (60.9%) than ever smokers (47.9%) presented with stage 4 disease. There was no statistical significant difference in OS between never smokers and ever smokers (11 versus 10 months; p = 0.3040). Tumor-related factors (stage and histologic differentiation) and treatment (surgery and chemotherapy) were independent prognostic factors for survival.
We found no statistical significant difference in clinicopathologic features or survival outcome between individual Asian American subgroup when analyzed according to smoking status.
我们之前报道过，在非小细胞肺癌（NSCLC）患者中，亚洲人种是一个有利于总生存期（OS）的预后因素，这与吸烟状态无关。然而，亚洲人种代表了一个多样化和异质的人群。在本报告中，我们按吸烟状态比较了亚裔美国 NSCLC 患者亚组的临床病理特征。
分析了 1991 年至 2005 年间在加利福尼亚州南部三个县诊断的五个主要亚裔美国 NSCLC 患者亚组的临床病理特征。通过 Cox 多因素分析评估 OS 的预后因素。
共分析了 1124 例 NSCLC 患者：菲律宾裔美国人（37.0%）、越南裔美国人（32.8%）、日裔美国人（11.8%）、华裔美国人（11.7%）和韩裔美国人（6.7%）。这些患者中共有 25.7%为从不吸烟者。除了日裔美国人之外，大多数亚裔美国人都是土生土长的。从不吸烟者的中位年龄略低于吸烟者（分别为 66 岁和 68 岁，p=0.0507）。从不吸烟者中女性的比例为 72.7%，范围从韩裔美国女性的最低（66.7%）到日裔美国女性的最高（84.2%）。在女性患者中，越南裔美国人从不吸烟者的比例最高（65.5%）。显著更多的从不吸烟者（60.9%）比吸烟者（47.9%）出现 4 期疾病。从不吸烟者和吸烟者的 OS 之间没有统计学显著差异（11 个月比 10 个月；p=0.3040）。肿瘤相关因素（分期和组织学分化）和治疗（手术和化疗）是生存的独立预后因素。
当按吸烟状态分析时，我们在个体亚裔美国亚组的临床病理特征或生存结果方面没有发现统计学显著差异。
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