National Hospital Organization Kinki-Chuo Chest Medical Center, Kita-ku, Sakai, Osaka, Japan.
J Thorac Oncol. 2010 Jul;5(7):1001-10. doi: 10.1097/JTO.0b013e3181e2f607.
We previously reported that Asian ethnicity was a favorable prognostic factor for overall survival (OS) in non-small cell lung cancer (NSCLC). In this study, we performed a combined data analysis from a Japanese Cancer Registry and a regional California Cancer Registry to further validate this observation.
Retrospective population-based analysis of Japanese and Caucasian patients with NSCLC with known smoking status from the Japanese National Hospital Organization Study Group for Lung Cancer and a Southern California Regional Cancer Registry between 1991 and 2001.
A total of 15,185 Japanese and 13,332 US Caucasian patients were analyzed. Median age of Japanese patients was 68 years compared with 69 years for Caucasian patients (p < 0.0001). A total of 29.3% of Japanese compared with 7.3% Caucasian patients were never-smokers. Never-smoking status conferred significant improved OS for Japanese (p < 0.0001) and a trend for improved OS for Caucasian patients (p = 0.1282). Univariate analysis revealed Japanese patients with stage III (versus Caucasian; hazard ratio [HR] = 0.830, 95% confidence interval [CI]: 0.789-0.873, p < 0.0001) and IV disease (versus Caucasian; HR = 0.955, 95% CI: 0.915-0.997, p = 0.0369) had improved OS compared with Caucasian patients. Multivariate analysis revealed Japanese ethnicity (versus Caucasian; HR = 0.937, 95% CI: 0.898-0.978, p = 0.0028) and never-smoker status (versus ever-smoker; HR = 0.947, 95% CI: 0.909-0.987, p = 0.0104) to be independent favorable factors for OS in addition to younger age, female gender, early stage, and treatment received (surgery, radiation, and chemotherapy).
Japanese ethnicity when compared with Caucasian ethnicity and never-smoker status are independent favorable prognostic factors for OS in NSCLC.
我们之前报道过，亚洲人种是影响非小细胞肺癌（NSCLC）总生存期（OS）的有利预后因素。在这项研究中，我们对日本国立癌症组织肺癌研究组和加利福尼亚州南部癌症登记处的日本和高加索 NSCLC 患者进行了联合数据分析，以进一步验证这一观察结果。
对 1991 年至 2001 年间日本国立癌症组织肺癌研究组和加利福尼亚州南部癌症登记处的已知吸烟状况的日本和美国高加索 NSCLC 患者进行回顾性基于人群的分析。
共分析了 15185 名日本患者和 13332 名美国高加索患者。日本患者的中位年龄为 68 岁，而高加索患者为 69 岁（p<0.0001）。29.3%的日本患者从未吸烟，而只有 7.3%的高加索患者从不吸烟。从不吸烟状态为日本患者带来了显著的 OS 改善（p<0.0001），并为高加索患者带来了 OS 改善的趋势（p=0.1282）。单因素分析显示，III 期（与高加索相比；风险比[HR] = 0.830，95%置信区间[CI]：0.789-0.873，p<0.0001）和 IV 期（与高加索相比；HR = 0.955，95%CI：0.915-0.997，p=0.0369）的日本患者 OS 得到改善。多因素分析显示，与高加索患者相比，日本种族（与高加索相比；HR=0.937，95%CI：0.898-0.978，p=0.0028）和从不吸烟状态（与曾吸烟相比；HR=0.947，95%CI：0.909-0.987，p=0.0104）是 OS 的独立有利因素，此外还包括年龄较小、女性、早期分期和接受治疗（手术、放疗和化疗）。
与高加索人种相比，日本人种和从不吸烟状态是 NSCLC 患者 OS 的独立有利预后因素。
