评价多花山竹子（Sonn.）在实验动物中的抗溃疡活性。
Evalution of anti-ulcer activity of Polyalthia longifolia (Sonn.) Thwaites in experimental animals.
机构信息
Rofel Shri GM Bilakhia College of Pharmacy, Vapi (West)-396 191, Gujarat State, India.
出版信息
Indian J Pharmacol. 2008 Jun;40(3):126-8. doi: 10.4103/0253-7613.42306.
OBJECTIVE
To evaluate the anti-ulcer activity of ethanol extract of leaves of Polyalthia longifolia (Sonn.) Thwaites.
MATERIALS AND METHODS
The ethanol extract of Polyalthia longifolia was investigated for its anti-ulcer activity against aspirin plus pylorous ligation induced gastric ulcer in rats, HCl -Ethanol induced ulcer in mice and water immersion stress induced ulcer in rats at 300 mg/kg body weight.p.o.
RESULTS
A significant (P < 0.01, P < 0.001) anti ulcer activity was observed in all the models. Pylorous ligation showed significant (P< 0.01) reduction in gastric volume, free acidity and ulcer index as compared to control. It also showed 89.71% ulcer inhibition in HCl- Ethanol induced ulcer and 95.3% ulcer protection index in stress induced ulcer.
CONCLUSION
This present study indicates that P. longifolia leaves extract have potential anti ulcer activity in the three models tested.
目的
评价多花山竹子（Sonn.）Thwaites 的叶乙醇提取物的抗溃疡活性。
材料与方法
以 300mg/kg 体重灌胃的方式，对多花山竹子的乙醇提取物进行了抗溃疡活性研究，研究对象包括阿司匹林加幽门结扎诱导的大鼠胃溃疡、盐酸-乙醇诱导的小鼠溃疡和水浸应激诱导的大鼠溃疡。
结果
在所有模型中均观察到显著的（P<0.01，P<0.001）抗溃疡活性。与对照组相比，幽门结扎显著（P<0.01）降低了胃容量、游离酸度和溃疡指数。它还显示出在 HCl-乙醇诱导的溃疡中 89.71%的溃疡抑制作用和在应激诱导的溃疡中 95.3%的溃疡保护指数。
结论
本研究表明，多花山竹子叶提取物在三种测试模型中具有潜在的抗溃疡活性。
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