锡兰叶下珠叶提取物对实验动物胃损伤的保护作用。
Protective Effects of Capparis zeylanica Linn. Leaf Extract on Gastric Lesions in Experimental Animals.
作者信息
Sini Karanayil R, Sinha Barij N, Rajasekaran Aiyolu
机构信息
Department of Pharmaceutical Chemistry, Grace College of Pharmacy, Palakkad, India.
出版信息
Avicenna J Med Biotechnol. 2011 Jan;3(1):31-5.
The aim of the study was to study the anti-ulcer activity of the methanolic extract of the leaves of Capparis zeylanica Linn on experimental animal models. The methanol extract of Capparis zeylanica Linn. leaves was investigated for anti-ulcer activity against aspirin plus pylorus ligation induced gastric ulcer in rats. HCl-Ethanol induced ulcer in mice and indomethacin induced ulcer in rats at 200 mg/kg body weight p.o. A significant (p<0.01, p<0.001) anti-ulcer activity was observed in all the models. Pylorus ligation showed significant (p<0.01) reduction in gastric volume, free acidity and ulcer index as compared to control. It also showed 88.5% ulcer inhibition in HCl-ethanol induced ulcer and 83.78% inhibition in indomethacin induced ulcer.
本研究的目的是研究锡兰没食子树叶甲醇提取物对实验动物模型的抗溃疡活性。对锡兰没食子树叶的甲醇提取物进行了研究，以观察其对阿司匹林加幽门结扎诱导的大鼠胃溃疡、盐酸-乙醇诱导的小鼠溃疡以及吲哚美辛诱导的大鼠溃疡（口服剂量为200mg/kg体重）的抗溃疡活性。在所有模型中均观察到显著的（p<0.01，p<0.001）抗溃疡活性。与对照组相比，幽门结扎显示胃体积、游离酸度和溃疡指数显著（p<0.01）降低。在盐酸-乙醇诱导的溃疡中，其溃疡抑制率为88.5%，在吲哚美辛诱导的溃疡中，抑制率为83.78%。
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