Pingle Shubhangi K, Tumane Rajani G, Jawade Aruna A
National Institute of Miner's Health, JNARDDC Campus, Nagpur, India.
Indian J Occup Environ Med. 2008 Dec;12(3):107-11. doi: 10.4103/0019-5278.44690.
Neopterin is regarded as an early biomarker of the cellular immune response. This low molecular mass compound belongs to the class of pteridine and is a metabolite of guanosine triphosphate, which is produced by the activated macrophages and dendritic cells after stimulation with gamma-interferon. An international group acknowledges the fact that the levels of serum neopterin can be used as a marker of the effect of exposure to silica and other occupational diseases. The determination of neopterin is an innovative tool for monitoring diseases associated with the activation of cell-mediated immunity.
新蝶呤被视为细胞免疫反应的早期生物标志物。这种低分子量化合物属于蝶啶类，是三磷酸鸟苷的代谢产物，由γ干扰素刺激后活化的巨噬细胞和树突状细胞产生。一个国际小组承认血清新蝶呤水平可作为接触二氧化硅和其他职业病影响的标志物这一事实。新蝶呤的测定是监测与细胞介导免疫激活相关疾病的一种创新工具。
