Wang Zhengping, Dong Minyue, Chu Hongnu, He Jing
Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Acta Obstet Gynecol Scand. 2004 Nov;83(11):1067-70. doi: 10.1111/j.0001-6349.2004.00601.x.
The etiology of intrahepatic cholestasis of pregnancy (ICP), a pregnancy-specific complication, remains not completely understood. Some alterations of immunity in ICP were reported, but the profile of immune alteration was far from clarified. The aim of this investigation was to characterize the changes of serum levels of neopterin, a marker for the activation of macrophage, and soluble interleukin-2 receptor (sIL-2R), a marker for the activation of lymphocyte, in ICP.
Serum levels of neopterin and sIL-2R were assayed with enzyme linked immunosorbent assay (ELISA) in 30 patients with ICP and 30 normal pregnant women. Student's t-test was used for statistic analysis, and p < 0.05 was considered significant.
Compared with control, serum levels of neopterin (p < 0.005) and sIL-2R (p < 0.05) were increased significantly in women with ICP.
Activation of monocyte-macrophage and lymphocyte was demonstrated in ICP, and the participation of the activation of macrophage and lymphocyte in pathogenesis of the disease could be assumed.
妊娠肝内胆汁淤积症（ICP）是一种特定于妊娠的并发症，其病因尚未完全明确。有报道称ICP存在一些免疫改变，但免疫改变的全貌仍远未阐明。本研究的目的是明确巨噬细胞活化标志物新蝶呤以及淋巴细胞活化标志物可溶性白细胞介素-2受体（sIL-2R）在ICP患者血清中的水平变化。
采用酶联免疫吸附测定法（ELISA）检测30例ICP患者和30例正常孕妇血清中新蝶呤和sIL-2R的水平。采用学生t检验进行统计学分析，p<0.05被认为具有统计学意义。
与对照组相比，ICP患者血清中新蝶呤水平（p<0.005）和sIL-2R水平（p<0.05）显著升高。
ICP患者存在单核细胞-巨噬细胞和淋巴细胞的活化，推测巨噬细胞和淋巴细胞的活化参与了该疾病的发病机制。
