一名重型β地中海贫血患者的高溶血现象。
Hyperhemolysis in a patient with beta-thalassemia major.
作者信息
Morawakage Lakmali R, Perera B J C, Dias P D N, Wijewardana S K
出版信息
Asian J Transfus Sci. 2009 Jan;3(1):26-7. doi: 10.4103/0973-6247.45259.
Abstract
A case of hyperhemolysis in a 2-year-old boy with beta thalassemia major was noted. After several transfusions, he developed hyperhemolysis with a positive (C3d only) direct antiglobulin test (DAT) and no clinically significant RBC allo- or auto-antibodies. (There was a weak cold antibody, showing a narrow thermal range). Because there was no significant improvement with steroid and immunoglobulin infusions, cyclophosphamide therapy was tried with notable success.
摘要
发现一名2岁重型β地中海贫血男孩发生了高溶血情况。经过多次输血后，他出现了高溶血，直接抗球蛋白试验（DAT）呈阳性（仅C3d阳性），且无具有临床意义的红细胞同种或自身抗体。（存在一种弱冷凝集素，热反应范围较窄）。由于使用类固醇和免疫球蛋白输注后无明显改善，尝试使用环磷酰胺治疗并取得了显著成功。
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