College of Veterinary Medicine, Chonnam National University, Gwangju, Republic of Korea.
J Med Food. 2009 Dec;12(6):1348-52. doi: 10.1089/jmf.2008.1323.
Estradiol valerate (EV)-induced polycystic ovaries (PCOs) in rats cause the anovulation and cystic ovarian morphology. We investigated whether treatment with HemoHIM influences the ovarian morphology and the expression of nerve growth factor (NGF) in an EV-induced PCO rat model. PCO was induced by a single intramuscular injection of EV (4 mg, dissolved in sesame oil) in adult cycling rats. HemoHIM was either administered orally (100 mg/kg of body weight/day) for 35 consecutive days or injected intraperitoneally (50 mg/kg of body weight) every other day after EV injection. Ovarian morphology was almost normalized, and NGF was normalized in the PCO + HemoHIM group. HemoHIM lowered the high numbers of antral follicles and increased the number of corpora lutea in PCOs. The results are consistent with a beneficial effect of HemoHIM in the prevention and treatment of PCO syndrome.
戊酸雌二醇（EV）诱导的大鼠多囊卵巢（PCO）导致无排卵和囊性卵巢形态。我们研究了 HemoHIM 治疗是否会影响 EV 诱导的 PCO 大鼠模型中的卵巢形态和神经生长因子（NGF）的表达。通过向成年发情大鼠单次肌肉注射 EV（溶于芝麻油中的 4mg）诱导 PCO。HemoHIM 连续 35 天口服（100mg/kg 体重/天）或在 EV 注射后每隔一天腹膜内注射（50mg/kg 体重）。PCO+HemoHIM 组的卵巢形态几乎正常化，NGF 正常化。HemoHIM 降低了 PCO 中大量的窦卵泡数量并增加了黄体数量。结果表明 HemoHIM 对 PCOS 综合征的预防和治疗具有有益作用。
