National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA.
Inhal Toxicol. 2010 Feb;22(2):125-32. doi: 10.3109/08958370902953910.
1-Bromopropane (1-BP) is categorized as a high-production-volume chemical and is currently used in the manufacture of pharmaceuticals, pesticides, and other chemicals. Its usage is estimated to be around 5 million pounds per year, resulting in the potential for widespread exposure in the workplace. Case reports and animal studies have suggested exposure to this compound may cause adverse reproductive and neurological effects. Using a battery of immunological assays, the immunotoxicity of 1-BP after whole body inhalation exposure in both mice and rats was evaluated. Significant decreases in the spleen immunoglobulin (Ig) M response to sheep red blood cells (SRBC) were observed in both mice (125-500 ppm) and rats (1000 ppm) after exposure to 1-BP for 10 wk. In addition, total spleen cells and T cells were significantly decreased after approximately 4 wk of 1-BP exposure in both mice (125-500 ppm) and rats (1000 ppm). No change in natural killer (NK) cell activity was observed. The observed alterations in spleen cellularity, phenotypic subsets, and impairment of humoral immune function across species raise further concern about human exposure to 1-BP and demonstrate the need for additional investigations into potential adverse health effects.
1-溴丙烷（1-BP）被归类为高产量化学品，目前用于制药、农药和其他化学品的制造。据估计，其年用量约为 500 万磅，因此在工作场所可能会广泛接触到这种化合物。病例报告和动物研究表明，接触这种化合物可能会对生殖和神经系统产生不良影响。本研究使用一系列免疫学检测方法，评估了全身吸入暴露于 1-BP 后对小鼠和大鼠的免疫毒性。结果发现，在暴露于 1-BP 10 周后，小鼠（125-500 ppm）和大鼠（1000 ppm）的脾脏免疫球蛋白（Ig）M 对绵羊红细胞（SRBC）的反应均显著降低。此外，在暴露于 1-BP 约 4 周后，小鼠（125-500 ppm）和大鼠（1000 ppm）的脾脏总细胞数和 T 细胞数也显著减少。自然杀伤（NK）细胞活性没有变化。在不同物种中观察到的脾脏细胞数量、表型亚群的改变以及体液免疫功能的损害，进一步引起了对人类接触 1-BP 的担忧，并表明需要进一步调查其对潜在健康影响的可能性。
