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使用新型胶水的家具制造商中的严重疾病:1-溴丙烷毒性与砷中毒混淆

Severe illness in furniture makers using a new glue: 1-bromopropane toxicity confounded by arsenic.

作者信息

Raymond Lawrence W, Ford Marsha D

机构信息

Carolinas Poison Center and Department of Family Medicine, Carolinas Medical Center, Charlotte, North Carolina 28232, USA.

出版信息

J Occup Environ Med. 2007 Sep;49(9):1009-19. doi: 10.1097/JOM.0b013e318145b616.

DOI:10.1097/JOM.0b013e318145b616
PMID:17848857
Abstract

OBJECTIVE

To describe the illnesses of four workers with high concentrations of serum bromide after exposure to glue containing 1-bromopropane (1-BP).

METHODS

We reviewed all available clinical records, examined the workers, and obtained additional urinary arsenic values. We used standard autoanalyzer and other routine methods for blood and urinalysis.

RESULTS

All four workers had symptoms and abnormal physical findings when hospitalized, remaining symptomatic with abnormal examinations 3 months later. Milder symptoms persisted in two workers, 8 years after their initial illnesses. Both have returned to work. Follow-up was unavailable for the other two workers.

CONCLUSIONS

Severe illness occurred in four gluers after 1-BP exposures associated with elevated levels of serum bromide. All had elevated urinary arsenic concentrations, the source of which remains unknown, but which confound interpretation of the abnormal bromide levels and clinical findings present during the acute illnesses.

摘要

目的

描述4名接触含1-溴丙烷(1-BP)胶水后血清溴化物浓度高的工人的患病情况。

方法

我们查阅了所有可用的临床记录,对工人进行了检查,并获取了额外的尿砷值。我们使用标准自动分析仪和其他常规方法进行血液和尿液分析。

结果

所有4名工人住院时均有症状和异常体征,3个月后检查仍有症状且异常。两名工人在初次患病8年后仍有较轻症状。两人均已重返工作岗位。另外两名工人无法进行随访。

结论

4名胶水工人在接触1-BP后出现严重疾病,血清溴化物水平升高。所有人的尿砷浓度均升高,其来源尚不清楚,但这混淆了对急性疾病期间异常溴化物水平和临床表现的解释。

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