Center for Environmental Health Sciences, College of Health Professions and Biomedical Sciences, University of Montana, Missoula, Montana, USA.
Inhal Toxicol. 2010 Feb;22(2):104-7. doi: 10.3109/08958370903008870.
The International Biomass Smoke Health Effects (IBSHE) conference was convened in Missoula, MT, to define our current knowledge of smoke exposure and the potential health effects. In an effort to ascertain the relative health effects of an exposure to biomass smoke, numerous studies have utilized either animal or in vitro systems. A wide variety of systems that have been employed ranged from more mainstream animal models (i.e., rodents) and transformed cell lines to less common animal (piglets and dogs) and explant models. The Toxicology and Animal Study Design Workgroup at IBSHE was tasked with an analysis of the use of animal models in the assessment of the health effects of biomass smoke exposure. The present article contains a mini-review of models utilized historically, in addition to the adverse health effects assessed, and an overview of the discussion within the breakout session. The most common question that arose in discussions at the IBSHE conference was from local and federal health departments: What level of smoke is unhealthy? The present workgroup determined categories of exposure, common health concerns, and the availability of animal models to answer key health questions.
国际生物质烟雾健康效应（IBSHE）会议在蒙大拿州米苏拉市召开，旨在确定我们目前对烟雾暴露和潜在健康影响的了解。为了确定暴露于生物质烟雾的相对健康影响，许多研究都利用了动物或体外系统。已经采用了各种各样的系统，包括更主流的动物模型（即啮齿动物）和转化细胞系，以及不太常见的动物（仔猪和狗）和外植体模型。IBSHE 的毒理学和动物研究设计工作组负责分析动物模型在评估生物质烟雾暴露对健康影响中的应用。本文包含对历史上使用的模型的简要回顾，以及评估的不良健康影响概述，以及分组讨论中的概述。在 IBSHE 会议的讨论中最常出现的问题是来自地方和联邦卫生部门的问题：什么样的烟雾是不健康的？本工作组确定了暴露类别、常见健康问题以及可用于回答关键健康问题的动物模型的可用性。
