Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA 98195-7234, USA.
Inhal Toxicol. 2010 Feb;22(2):99-103. doi: 10.3109/08958370903008862.
It has been clearly established that exposure to wood smoke is associated with a variety of adverse health effects in humans. However, we still have much to learn about the relationship between wood-smoke exposure and disease, including determination of what should be considered a "safe" level of exposure, and whether wood smoke should be regulated separately from other sources of air pollution. To help answer these questions, improved measures of exposure in populations exposed to wood smoke are required. In this mini-review we discuss how biomarkers of exposure can be used to complement the current suite of methods used to assess wood-smoke exposures. We critically review the compounds that are currently being evaluated as biomarkers of exposure to wood smoke, and we identify the strengths and weaknesses of these compounds. We find that, in general, these compounds show promise in situations where wood-smoke exposures are high, but where exposures are low non-wood-smoke sources are likely to be the major determinants of biomarker levels. We also outline a research framework that will move this field forward and maximize the potential for wood-smoke biomarkers to add value to epidemiological studies of wood-smoke health effects.
已经明确证实，人类接触木柴烟雾会导致各种健康不良影响。然而，我们仍然需要更多地了解木柴烟雾暴露与疾病之间的关系，包括确定什么应该被认为是“安全”的暴露水平，以及是否应该将木柴烟雾与其他空气污染源分开进行监管。为了帮助回答这些问题，需要在接触木柴烟雾的人群中提高暴露的测量方法。在这篇小型综述中，我们讨论了如何使用暴露生物标志物来补充当前用于评估木柴烟雾暴露的方法。我们批判性地审查了目前被评估为暴露于木柴烟雾的生物标志物的化合物，并确定了这些化合物的优缺点。我们发现，一般来说，这些化合物在木柴烟雾暴露水平较高的情况下有很大的潜力，但在暴露水平较低的情况下，非木柴烟雾源可能是生物标志物水平的主要决定因素。我们还概述了一个研究框架，将推动这一领域的发展，并最大限度地发挥木柴烟雾生物标志物在流行病学研究中的价值，以研究木柴烟雾对健康的影响。
