老年骨髓增生异常综合征患者：CBC 与细胞遗传学和 FISH 分析的相关性。
Myelodysplastic syndrome in elderly patients: correlation of CBC with cytogenetic and FISH analysis.
机构信息
Department of Pathology, The George Washington University Medical Center, NW, Washington, DC, USA.
出版信息
Int J Lab Hematol. 2010 Aug 1;32(4):443-8. doi: 10.1111/j.1751-553X.2009.01210.x. Epub 2009 Dec 23.
Unexplained anemia in the elderly could represent myelodysplastic syndrome (MDS). We assessed the utility of using a fluorescence in situ hybridization (FISH) panel for common chromosomal abnormalities seen in MDS. A total of 101 elderly outpatients with anemia of unknown etiology were evaluated. Complete blood count, bone marrow biopsy, conventional cytogenetic analysis (CC), and FISH panel were reviewed. A total of 21 (21%) of the 101 patients had MDS. A combination of CC and FISH identified chromosomal abnormalities in 17 (81%) of the patients with MDS. The remaining 4 (19%) were diagnosed with MDS based solely on morphologic criteria. Except in two cases, FISH did not reveal abnormalities not already detected by CC. Furthermore, MDS patients infrequently had isolated anemia (14%) as opposed to those without MDS (75%). A MDS FISH panel is not more sensitive than CC in elderly outpatients with unexplained anemia. MDS is more likely if in addition to anemia, leukopenia and/or thrombocytopenia are also present.
老年人不明原因的贫血可能代表骨髓增生异常综合征（MDS）。我们评估了使用荧光原位杂交（FISH）检测常见染色体异常在 MDS 中的应用。共评估了 101 例病因不明贫血的老年门诊患者。回顾了全血细胞计数、骨髓活检、常规细胞遗传学分析（CC）和 FISH 检测。101 例患者中共有 21 例（21%）患有 MDS。CC 和 FISH 的联合检测可识别出 17 例（81%）MDS 患者的染色体异常。其余 4 例（19%）仅根据形态学标准诊断为 MDS。除了两种情况，FISH 未发现 CC 已检测到的异常。此外，与无 MDS 患者（75%）相比，MDS 患者贫血（14%）更为少见。对于不明原因贫血的老年门诊患者，MDS FISH 检测并不比 CC 更敏感。如果除贫血外还伴有白细胞减少和/或血小板减少，则更有可能发生 MDS。
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