Nesselmann Catharina, Li Wenzhong, Ma Nan, Steinhoff Gustav
Department of Cardiac Surgery, University of Rostock, Germany.
Ther Adv Cardiovasc Dis. 2010 Feb;4(1):27-42. doi: 10.1177/1753944709353338. Epub 2009 Dec 30.
Accumulating clinical and experimental evidence indicates that stem cells from various sources are promising in the treatment of cardiac dysfunction. They may be incorporated into neovascular foci and thus contribute to postnatal physiological and pathological vasculogenesis and/or produce a variety of growth factors for angiogenesis and cytokines that home other stem cells from other organs for cardiac regeneration. This review focuses on the neovascularization of stem cells from different sources in cardiac repair, with emphasis on adult stem cells.
越来越多的临床和实验证据表明，来自各种来源的干细胞在治疗心脏功能障碍方面很有前景。它们可能会整合到新生血管灶中，从而促进出生后的生理性和病理性血管生成，和/或产生多种促进血管生成的生长因子以及细胞因子，这些细胞因子能将其他器官的干细胞归巢至心脏以实现心脏再生。本综述着重探讨不同来源的干细胞在心脏修复中的血管生成，重点是成体干细胞。
