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1
Akt1 and Akt2 promote peripheral B-cell maturation and survival.
Blood. 2010 May 20;115(20):4043-50. doi: 10.1182/blood-2009-09-241638. Epub 2009 Dec 30.
2
AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species.
Blood. 2010 May 20;115(20):4030-8. doi: 10.1182/blood-2009-09-241000. Epub 2010 Mar 30.
6
Only Akt1 is required for proliferation, while Akt2 promotes cell cycle exit through p21 binding.
Mol Cell Biol. 2006 Nov;26(22):8267-80. doi: 10.1128/MCB.00201-06. Epub 2006 Sep 18.
8
Unique roles of Akt1 and Akt2 in IGF-IR mediated lung tumorigenesis.
Oncotarget. 2016 Jan 19;7(3):3297-316. doi: 10.18632/oncotarget.6489.
10
Opposing roles for Akt1 and Akt2 in Rac/Pak signaling and cell migration.
J Biol Chem. 2006 Nov 24;281(47):36443-53. doi: 10.1074/jbc.M600788200. Epub 2006 Oct 1.

引用本文的文献

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The function of serine/threonine-specific protein kinases in B cells.
Front Immunol. 2024 Oct 9;15:1459527. doi: 10.3389/fimmu.2024.1459527. eCollection 2024.
2
The essential roles of lncRNAs/PI3K/AKT axis in gastrointestinal tumors.
Front Cell Dev Biol. 2024 Aug 5;12:1442193. doi: 10.3389/fcell.2024.1442193. eCollection 2024.
3
Pediococcus pentosaceus MIANGUAN Enhances the Immune Response to Vaccination in Mice.
Probiotics Antimicrob Proteins. 2024 Aug;16(4):1117-1129. doi: 10.1007/s12602-023-10205-z. Epub 2024 Jan 2.
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Bifunctional Inhibitor Reveals NEK2 as a Therapeutic Target and Regulator of Oncogenic Pathways in Lymphoma.
Mol Cancer Ther. 2024 Mar 4;23(3):316-329. doi: 10.1158/1535-7163.MCT-23-0299.
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Integrative proteomics, phosphoproteomics and acetylation proteomics analyses of acute pancreatitis in rats.
Int J Med Sci. 2023 May 11;20(7):888-900. doi: 10.7150/ijms.81658. eCollection 2023.
6
Regulation of the immune system by the insulin receptor in health and disease.
Front Endocrinol (Lausanne). 2023 Mar 13;14:1128622. doi: 10.3389/fendo.2023.1128622. eCollection 2023.
7
PI3K Isoforms in B Cells.
Curr Top Microbiol Immunol. 2022;436:235-254. doi: 10.1007/978-3-031-06566-8_10.
8
Defects in aminoacyl-tRNA synthetase cause partial B and T cell immunodeficiency.
Cell Mol Life Sci. 2022 Jan 23;79(2):87. doi: 10.1007/s00018-021-04122-z.
9
Nck adaptors at a glance.
J Cell Sci. 2021 Sep 15;134(18). doi: 10.1242/jcs.258965. Epub 2021 Sep 24.
10
Pax5 regulates B cell immunity by promoting PI3K signaling via PTEN down-regulation.
Sci Immunol. 2021 Jul 23;6(61). doi: 10.1126/sciimmunol.abg5003.

本文引用的文献

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PI3 kinase signals BCR-dependent mature B cell survival.
Cell. 2009 Oct 30;139(3):573-86. doi: 10.1016/j.cell.2009.08.041.
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Tonic B cell antigen receptor signals supply an NF-kappaB substrate for prosurvival BLyS signaling.
Nat Immunol. 2008 Dec;9(12):1379-87. doi: 10.1038/ni.1666. Epub 2008 Nov 2.
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BAFF activates Akt and Erk through BAFF-R in an IKK1-dependent manner in primary mouse B cells.
Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12435-8. doi: 10.1073/pnas.0805460105. Epub 2008 Aug 19.
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Foxo1 directly regulates the transcription of recombination-activating genes during B cell development.
Nat Immunol. 2008 Jun;9(6):613-22. doi: 10.1038/ni.1612. Epub 2008 May 11.
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Peripheral B cell subsets.
Curr Opin Immunol. 2008 Apr;20(2):149-57. doi: 10.1016/j.coi.2008.03.014. Epub 2008 Apr 21.
7
Akt1 and Akt2 are required for alphabeta thymocyte survival and differentiation.
Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12105-10. doi: 10.1073/pnas.0705285104. Epub 2007 Jul 3.
8
AKT/PKB signaling: navigating downstream.
Cell. 2007 Jun 29;129(7):1261-74. doi: 10.1016/j.cell.2007.06.009.
9
Unequal contribution of Akt isoforms in the double-negative to double-positive thymocyte transition.
J Immunol. 2007 May 1;178(9):5443-53. doi: 10.4049/jimmunol.178.9.5443.
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Generation of peripheral B cells occurs via two spatially and temporally distinct pathways.
Blood. 2007 Mar 15;109(6):2521-8. doi: 10.1182/blood-2006-04-018085. Epub 2006 Nov 14.

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