Institute of Animal Physiology and Genetics CAS v.v.i., Brno, Czech Republic.
J Dent Res. 2010 Feb;89(2):108-15. doi: 10.1177/0022034509355440. Epub 2009 Dec 30.
Not only are teeth essential for mastication, but also missing teeth are considered a social handicap due to speech and aesthetic problems, with a resulting high impact on emotional well-being. Several treatment procedures are currently available for tooth replacement with mostly inert prosthetic materials and implants. Natural tooth substitution based on copying the developmental process of tooth formation is particularly challenging and creates a rapidly developing area of molecular dentistry. In any approach, functional interactions among the tooth, the surrounding bone, and the periodontium must be established. Therefore, recent research in craniofacial genetics searches for mechanisms responsible for correct cell and tissue interactions, not only within a specific structure, but also in the context of supporting structures. A tooth crown that is not functionally anchored to roots and bone is useless. This review aims to summarize the developmental and tissue homeostatic aspects of the tooth-bone interface, from the initial patterning toward tooth eruption and lifelong interactions between the tooth and its surrounding alveolar bone.
牙齿不仅对于咀嚼至关重要，而且由于言语和美观问题缺失牙齿也被认为是一种社会障碍，对情感健康有很大影响。目前有几种治疗方法可用于牙齿替代，主要使用惰性的义齿材料和植入物。基于模仿牙齿形成发育过程的天然牙齿替代特别具有挑战性，并且正在形成一个分子牙科学的快速发展领域。在任何方法中，都必须建立牙齿、周围骨骼和牙周组织之间的功能相互作用。因此，颅面遗传学的最近研究正在寻找负责正确细胞和组织相互作用的机制，不仅在特定结构内，而且在支持结构的背景下也是如此。没有与根和骨功能连接的牙冠是无用的。本文旨在总结牙齿-骨骼界面的发育和组织动态平衡方面，从初始模式化到牙齿萌出以及牙齿与其周围牙槽骨的终生相互作用。
