前世界贸易中心救援人员和志愿者中的打鼾和阻塞性睡眠呼吸暂停。
Snoring and obstructive sleep apnea among former World Trade Center rescue workers and volunteers.
机构信息
Department of Preventive Medicine, Mount Sinai School of Medicine, New York, NY, USA.
出版信息
J Occup Environ Med. 2010 Jan;52(1):29-32. doi: 10.1097/JOM.0b013e3181c2bb18.
BACKGROUND
Snoring is a common symptom among workers with adverse health effects from their World Trade Center (WTC) occupational exposures. Rhinitis and upper airway disease are highly prevalent among these workers. Rhinitis has been associated with snoring and, in some studies, with obstructive sleep apnea (OSA). We examined the association of WTC exposure and findings on nocturnal polysomnogram, as well as known predictors of OSA in this patient population.
METHODS
One hundred participants with snoring underwent a polysomnogram to exclude OSA. Comorbidities had been previously evaluated and treated. The apnea-hypopnea index (AHI) defined and categorized the severity of OSA. Age, sex, body mass index (BMI), and WTC exposure variables were examined in bivariate and multiple regression analyses.
RESULTS
Our study sample had a similar prevalence of five major disease categories, as we previously reported. OSA was diagnosed in 62% of the patients and was not associated with any of those disease categories. A trend toward increasing AHI with increasing WTC exposure duration failed to reach the statistical significance (P = 0.14) in multiple regression analysis. An elevated AHI was associated with BMI (P = 0.003) and male sex (P < 0.001).
CONCLUSIONS
OSA was associated with BMI and male sex but not with occupational WTC exposure indicators in this patient population.
背景
打鼾是接触世界贸易中心（WTC）职业暴露的工人中常见的健康影响症状。这些工人中鼻炎和上呼吸道疾病的患病率很高。鼻炎与打鼾有关，在某些研究中与阻塞性睡眠呼吸暂停（OSA）有关。我们研究了 WTC 暴露与夜间多导睡眠图检查结果之间的关系，以及该患者人群中 OSA 的已知预测因素。
方法
100 名打鼾患者接受了多导睡眠图检查以排除 OSA。先前已经评估和治疗了合并症。呼吸暂停低通气指数（AHI）定义并分类了 OSA 的严重程度。在单变量和多变量回归分析中检查了年龄、性别、体重指数（BMI）和 WTC 暴露变量。
结果
我们的研究样本与我们之前报告的五个主要疾病类别具有相似的患病率。62%的患者被诊断为 OSA，但与任何这些疾病类别均无关。在多变量回归分析中，随着 WTC 暴露时间的增加，AHI 呈增加趋势，但未达到统计学意义（P=0.14）。较高的 AHI 与 BMI（P=0.003）和男性性别（P<0.001）相关。
结论
在该患者人群中，OSA 与 BMI 和男性性别有关，但与职业性 WTC 暴露指标无关。
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