Department of Otolaryngology-Head and Neck Surgery.
College of Medicine.
Otol Neurotol. 2018 Jul;39(6):e475-e480. doi: 10.1097/MAO.0000000000001805.
To determine the prevalence of obstructive sleep apnea (OSA) in a prospective cohort of patients with spontaneous CSF (sCSF) leaks of the temporal bone.
Prospective cohort study.
Tertiary referral center.
Consecutive sCSF leak patients (21) over a 3-year period. Four patients presented with a history of OSA and 17 patients were prospectively offered polysomnogram (PSG) testing during the initial clinic encounter.
Level I PSG.
Patient characteristics (age, sex, body mass index), apnea hypopnea index (AHI), presence of snoring, and presence of hypoxia (oxygen saturation <88% for >5 min). OSA was defined as mild (AHI ≥5 and <15/h), moderate (AHI ≥15 and <30/h), and severe (AHI ≥30/h).
The prevalence of OSA in sCSF leak patients is 83.3%. PSG studies were performed on 18 of the 21 patients. There were 15 women and 6 men with an average age (standard deviation) of 56.3 (11.2) years and an average body mass index of 35.3 (7.7) kg/m. Objectively, the AHI ranged from mild to severe (range = 5.7-92, median = 19.8). Snoring was present in 61% of patients and hypoxia was present in 39% of patients. sCSF leak patients with OSA were significantly older than sCSF leak patients without OSA (56.7 [8.3] versus 42.7 [14.5] yr, p = 0.03).
OSA is highly prevalent among patients with sCSF leaks. All patients with sCSF leaks should undergo formal PSG testing. Future studies are needed to determine the role of OSA in the development of sCSF leaks.
确定颞骨自发性脑脊髓液（sCSF）漏患者前瞻性队列中阻塞性睡眠呼吸暂停（OSA）的患病率。
前瞻性队列研究。
三级转诊中心。
在 3 年期间连续出现 sCSF 漏的患者（21 例）。4 例患者有 OSA 病史，17 例患者在首次就诊时前瞻性地接受了多导睡眠图（PSG）检查。
I 级 PSG。
患者特征（年龄、性别、体重指数）、呼吸暂停低通气指数（AHI）、打鼾和缺氧（氧饱和度<88%超过 5 分钟）。OSA 定义为轻度（AHI≥5 且<15/h）、中度（AHI≥15 且<30/h）和重度（AHI≥30/h）。
sCSF 漏患者的 OSA 患病率为 83.3%。对 21 例患者中的 18 例进行了 PSG 研究。患者中有 15 名女性和 6 名男性，平均年龄（标准差）为 56.3（11.2）岁，平均体重指数为 35.3（7.7）kg/m。客观上，AHI 从轻度到重度不等（范围=5.7-92，中位数=19.8）。61%的患者存在打鼾，39%的患者存在缺氧。有 OSA 的 sCSF 漏患者明显比没有 OSA 的 sCSF 漏患者年龄更大（56.7[8.3]岁比 42.7[14.5]岁，p=0.03）。
OSA 在 sCSF 漏患者中患病率很高。所有 sCSF 漏患者均应进行正式的 PSG 检查。需要进一步的研究来确定 OSA 在 sCSF 漏发展中的作用。
