食管外反流（EER）与阻塞性睡眠呼吸暂停（OSA）之间的关系。
The relationship between extraesophageal reflux (EER) and obstructive sleep apnea (OSA).
作者信息
Zanation Adam M, Senior Brent A
机构信息
Department of Otolaryngology/Head and Neck Surgery, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
出版信息
Sleep Med Rev. 2005 Dec;9(6):453-8. doi: 10.1016/j.smrv.2005.05.003. Epub 2005 Sep 22.
Obstructive sleep apnea (OSA) and extraesophageal reflux (EER) are common chronic diseases and share several similar risk factors. The prevalence of gastroesophogeal (GERD) in OSA patients is significantly higher than the general population; however, no temporal or causal relationship has ever been demonstrated between the two. The purpose of this review is to understand the association between obstructive sleep apnea (OSA) and extraesophageal reflux disease (EER) in the adult population. We conclude that CPAP treatment of OSA significantly reduces GERD symptoms and acidic pH exposure in the esophagus and this improvement with CPAP physiologically occurs in the presence or absence of OSA; and treatment of GERD in OSA patients improves the number of arousals during sleep, but only one study showed a significant difference in apnea.
阻塞性睡眠呼吸暂停（OSA）和食管外反流（EER）是常见的慢性疾病，且有几个相似的风险因素。OSA患者中胃食管反流病（GERD）的患病率显著高于普通人群；然而，两者之间从未被证实存在时间或因果关系。本综述的目的是了解成年人群中阻塞性睡眠呼吸暂停（OSA）与食管外反流病（EER）之间的关联。我们得出结论，持续气道正压通气（CPAP）治疗OSA可显著减轻GERD症状并减少食管内酸性pH暴露，且无论是否存在OSA，CPAP治疗均会在生理上带来这种改善；治疗OSA患者的GERD可改善睡眠中的觉醒次数，但仅有一项研究显示在呼吸暂停方面有显著差异。
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