Ritfeld Gaby J, Nandoe Tewarie Rishi D, Rahiem Sahar T, Hurtado Andres, Roos Raymund A, Grotenhuis Andre, Oudega Martin
Department of Physical Medicine and Rehabilitation, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA.
Neuroreport. 2010 Feb 17;21(3):221-6. doi: 10.1097/WNR.0b013e32833677cd.
We tested whether reducing macrophage infiltration would improve the survival of allogeneic bone marrow stromal cells (BMSC) transplanted in the contused adult rat thoracic spinal cord. Treatment with cyclosporine, minocycline, or methylprednisolone all resulted in a significant decrease in macrophage infiltration at 3 days postinjury. However, when BMSC were injected at that time point, survival 7 days later was similar between treatment groups and saline-injected controls. In fact, we found that the presence of BMSC resulted in a significant increase in macrophage infiltration into the contusion.
我们测试了减少巨噬细胞浸润是否会提高同种异体骨髓基质细胞（BMSC）移植到成年大鼠胸段脊髓挫伤部位后的存活率。用环孢素、米诺环素或甲基强的松龙治疗均导致损伤后3天巨噬细胞浸润显著减少。然而，当在该时间点注射BMSC时，7天后各治疗组与注射生理盐水的对照组的细胞存活率相似。事实上，我们发现BMSC的存在导致挫伤部位巨噬细胞浸润显著增加。
