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帕唑帕尼。

Pazopanib.

出版信息

Nat Rev Drug Discov. 2010 Jan;9(1):17-8. doi: 10.1038/nrd3073.

DOI:10.1038/nrd3073
PMID:20043026
Abstract

In October 2009, pazopanib (Votrient; GlaxoSmithKline)--a multikinase inhibitor with targets that include vascular endothelial growth factor receptors--was approved by the US FDA for the treatment of advanced renal cell carcinoma.

摘要

2009 年 10 月,帕唑帕尼(培唑帕尼;葛兰素史克)——一种具有包括血管内皮生长因子受体在内的多种激酶靶点的抑制剂——被美国食品药品监督管理局批准用于治疗晚期肾细胞癌。

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Pazopanib.帕唑帕尼。
Nat Rev Drug Discov. 2010 Jan;9(1):17-8. doi: 10.1038/nrd3073.
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Hyperactivated YAP1 is essential for sustainable progression of renal clear cell carcinoma.YAP1过度激活对于肾透明细胞癌的持续进展至关重要。
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Clinical advances and challenges in targeting FGF/FGFR signaling in lung cancer.

本文引用的文献

1
Everolimus.依维莫司
Nat Rev Drug Discov. 2009 Jul;8(7):535-6. doi: 10.1038/nrd2924.
2
Anti-angiogenic targets in the treatment of advanced renal cell carcinoma.抗血管生成靶点在晚期肾细胞癌治疗中的应用
Curr Cancer Drug Targets. 2008 Dec;8(8):676-82. doi: 10.2174/156800908786733450.
3
Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial.依维莫司治疗晚期肾细胞癌的疗效:一项双盲、随机、安慰剂对照的III期试验。
在肺癌中靶向 FGF/FGFR 信号的临床进展和挑战。
Mol Cancer. 2024 Nov 15;23(1):256. doi: 10.1186/s12943-024-02167-9.
4
Systematic Evaluation of Tyrosine Kinase Inhibitors as OATP1B1 Substrates Using a Competitive Counterflow Screen.采用竞争逆流筛选法对酪氨酸激酶抑制剂作为 OATP1B1 底物的系统评价。
Cancer Res Commun. 2024 Sep 1;4(9):2489-2497. doi: 10.1158/2767-9764.CRC-24-0332.
5
Synthesis, molecular docking and molecular dynamics simulations, drug-likeness studies, ADMET prediction and biological evaluation of novel pyrazole-carboxamides bearing sulfonamide moiety as potent carbonic anhydrase inhibitors.新型含磺酰胺基团的吡唑甲酰胺作为高效碳酸酐酶抑制剂的合成、分子对接和分子动力学模拟、类药性研究、ADMET预测及生物学评价
Mol Divers. 2025 Apr;29(2):1207-1227. doi: 10.1007/s11030-024-10901-0. Epub 2024 Jun 13.
6
Linoleate-pazopanib conjugation as active pharmacological ingredient to abolish hepatocellular carcinoma growth.亚油酸酯-帕唑帕尼缀合物作为活性药物成分抑制肝细胞癌生长。
Front Pharmacol. 2024 Jan 16;14:1281067. doi: 10.3389/fphar.2023.1281067. eCollection 2023.
7
Immunotherapies targeting tumor vasculature: challenges and opportunities.针对肿瘤血管的免疫疗法:挑战与机遇。
Front Immunol. 2023 Sep 1;14:1226360. doi: 10.3389/fimmu.2023.1226360. eCollection 2023.
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Advances in treatment of alveolar soft part sarcoma: an updated review.肺泡软组织肉瘤治疗进展:更新综述。
Jpn J Clin Oncol. 2023 Nov 5;53(11):1009-1018. doi: 10.1093/jjco/hyad102.
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Antitumor Therapy Targeting the Tumor Microenvironment.靶向肿瘤微环境的抗肿瘤治疗
J Oncol. 2023 Mar 3;2023:6886135. doi: 10.1155/2023/6886135. eCollection 2023.
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Using a zebrafish xenograft tumor model to compare the efficacy and safety of VEGFR-TKIs.利用斑马鱼异种移植肿瘤模型比较 VEGFR-TKIs 的疗效和安全性。
J Cancer Res Clin Oncol. 2023 Aug;149(9):5975-5987. doi: 10.1007/s00432-022-04560-7. Epub 2023 Jan 7.
Lancet. 2008 Aug 9;372(9637):449-56. doi: 10.1016/S0140-6736(08)61039-9. Epub 2008 Jul 22.
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Discovery of 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a novel and potent vascular endothelial growth factor receptor inhibitor.新型强效血管内皮生长因子受体抑制剂5-[[4-[(2,3-二甲基-2H-吲唑-6-基)甲基氨基]-2-嘧啶基]氨基]-2-甲基苯磺酰胺(帕唑帕尼)的发现
J Med Chem. 2008 Aug 14;51(15):4632-40. doi: 10.1021/jm800566m. Epub 2008 Jul 12.
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Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity.帕唑帕尼是一种具有强大抗肿瘤和抗血管生成活性的多激酶血管生成抑制剂,从小鼠到人类的药代动力学-药效学相关性。
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