Marazuela M, Yebra M, Girón J A, Menéndez J L, Vargas J A, España P, Garcia-Font M, Durántez A
Service of Internal Medicine I, Clinica Puerta de Hierro Madrid, Spain.
Cancer. 1991 Apr 1;67(7):1950-3. doi: 10.1002/1097-0142(19910401)67:7<1950::aid-cncr2820670721>3.0.co;2-d.
Histologic conversion from a low-grade non-Hodgkin's lymphoma (NHL) into a more aggressive histologic pattern is a common, well-documented event in NHL. The converse phenomenon, appearance of a low-grade, follicular NHL after treatment for diffuse, intermediate, or high-grade NHL, has only recently been recognized. The clinical, morphologic, and immunologic features of a patient in whom relapse with an indolent nodular lymphoma was noticed after combination chemotherapy for diffuse lymphoma are presented. Immunologic markers at presentation and relapse were similar. Other previously reported cases are reviewed. Implications for diagnosis and therapy as well as the pathogenesis of this unique form of conversion are discussed.
从低度非霍奇金淋巴瘤（NHL）组织学转变为侵袭性更强的组织学类型，是NHL中一种常见且有充分文献记载的现象。相反的现象，即在弥漫性、中度或高度NHL治疗后出现低度滤泡性NHL，直到最近才被认识到。本文介绍了一名弥漫性淋巴瘤患者在联合化疗后复发为惰性结节性淋巴瘤的临床、形态学和免疫学特征。初诊和复发时的免疫标志物相似。还回顾了其他先前报道的病例。并讨论了这种独特转变形式对诊断和治疗的意义以及发病机制。
