Department of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, PR China.
Oncol Rep. 2010 Feb;23(2):321-8.
Inhibitors of DNA binding/inhibitors of differentiation (Id) protein family (Id-1, -2, -3 and -4) of helix-loop-helix proteins have been shown to be involved in carcinogenesis and are regarded as prognostic markers in several types of human cancers. However, the roles of Id proteins during breast carcinoma progression remain unclear. The objective was to study the effects of Id proteins in breast cancer. The expression of Id-1, Id-2, Id-3 and Id-4 proteins was examined in 122 dissected female human breast carcinoma tissues and 22 normal female breast specimens by immunohistochemical assay and the relationship between Id staining and clinical pathological characteristics of breast cancer was also analyzed. The over-expressed Id-1 and down-regulated Id-4 proteins were found both correlated with poorer differentiation and more aggressive behavior of the tumor. Id-1 protein could be termed as a negative prognostic marker while Id-4 protein as a positive marker for patients with breast carcinoma. Although the differentially expressed Id-2 and -3 may be correlated with some clinical parameters, they could not be used as independent prognostic factors in human breast cancer.
螺旋-环-螺旋蛋白家族的 DNA 结合抑制剂/分化抑制剂（Id）蛋白（Id-1、-2、-3 和 -4）已被证明参与了致癌作用，并被认为是几种人类癌症的预后标志物。然而，Id 蛋白在乳腺癌进展过程中的作用仍不清楚。本研究旨在探讨 Id 蛋白在乳腺癌中的作用。通过免疫组织化学检测，对 122 例女性乳腺癌组织和 22 例正常女性乳腺标本中的 Id-1、Id-2、Id-3 和 Id-4 蛋白的表达进行了研究，并分析了 Id 染色与乳腺癌临床病理特征之间的关系。结果发现，过表达的 Id-1 蛋白和下调的 Id-4 蛋白均与肿瘤分化不良和侵袭性增强有关。Id-1 蛋白可作为乳腺癌患者的负预后标志物，而 Id-4 蛋白可作为正预后标志物。虽然差异表达的 Id-2 和 -3 可能与某些临床参数相关，但它们不能作为人类乳腺癌的独立预后因素。
