School of Life Sciences, Huaiyin Normal University, Huaian, Jiangsu 223300, PR China.
Int J Mol Med. 2010 Feb;25(2):299-304.
Interferon (IFN)-lambdas, including IFN-lambda1, IFN-lambda2, and IFN-lambda3, are a newly described group of cytokines distantly related to the type I IFNs and IL-10 family members. Besides the antiviral activity, IFN-lambdas were reported to inhibit various tumor growths in vitro and in vivo. Herein, we identified IFN-lambda genes from the genome sequences of the human, chimpanzee, macaque, orangutan, mouse, rat and dog, and found that the locations and copy of a specific IFN-lambda varied in different genomes, not just the copy of IFN-lambdas. We found human IFN-lambdas were expressed in fetal retina, fetal brain and T cells by ESTs search. Moreover, IFN-lambdas were also found to express in bladder cancer, blood cancer, breast cancer, glioma, head and neck cancer and lung cancer tissues. Three tumor-related transcriptional factors (steroidogenic factor-1, Wilms tumor 1 and P53) binding sites were identified within the 1.0-kb regions upstream of the transcriptional start site of human IFN-lambdas. Meta-analysis of the prognostic value of IFN-lambda genes in various cancers showed that the expression of IFN-lambdas are indeed related to the cancer prognosis in certain types of cancer. It can be predicted that IFN-lambdas take part in the cancer development by the regulation of expression of IFN-lambdas related to the SF-1, P53 and WT-1.
干扰素（IFN）-lambda 包括 IFN-lambda1、IFN-lambda2 和 IFN-lambda3，是一类新发现的细胞因子，与 I 型干扰素和 IL-10 家族成员具有较远的亲缘关系。除了抗病毒活性外，IFN-lambda 还被报道具有抑制体外和体内多种肿瘤生长的作用。在此，我们从人类、黑猩猩、猕猴、猩猩、小鼠、大鼠和犬的基因组序列中鉴定出 IFN-lambda 基因，发现不同基因组中特定 IFN-lambda 的位置和拷贝数存在差异，而不仅仅是 IFN-lambda 的拷贝数。通过 EST 搜索，我们发现人类 IFN-lambda 在胎儿视网膜、胎儿大脑和 T 细胞中表达。此外，IFN-lambda 还在膀胱癌、血液癌、乳腺癌、神经胶质瘤、头颈癌和肺癌组织中表达。在人类 IFN-lambda 转录起始位点上游 1.0kb 区域内鉴定出三个与肿瘤相关的转录因子（甾体生成因子 1、Wilms 瘤 1 和 P53）结合位点。对 IFN-lambda 基因在各种癌症中的预后价值的荟萃分析表明，IFN-lambda 的表达确实与某些类型癌症的预后相关。可以预测，IFN-lambda 通过与 SF-1、P53 和 WT-1 相关的 IFN-lambda 表达的调节参与癌症的发展。
