Public Health College, Harbin Medical University, NanGang District, Harbin, P. R. China.
Nutr Cancer. 2010;62(1):58-65. doi: 10.1080/01635580903191510.
Recent chemopreventive studies from our group showed that dietary beta -ionone inhibited 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary carcinogenesis by the inhibition of cell proliferation and apoptosis initiation. In this study, we examined the chemopreventive effects of varied doses of dietary beta -ionone on the development and growth of DMBA-induced rat mammary tumors as well as plasma antioxidant status. beta -ionone treatment groups were given 9, 18, and 36 mmol/kg in the AIN76A diet starting 2 wk prior to DMBA administration and continuing for the 24 wk. Results showed that tumor incidence was dose dependently reduced by 35.4, 68.3, and 87.8%, respectively, compared to the positive control. Tumor sizes were dose dependently smaller, and tumor weight was less in each group, each rat, and each tumor compared to the positive control (P < 0.05). A significant decrease in lipid peroxidation was observed in the tumor-induced rats treated with dietary beta -ionone, whereas the plasma activities of antioxidant enzymes such as glutathione peroxidase, glutathione reductase, superoxide dismutase, and the nonenzymatic antioxidant glutathione were increased in the beta -ionone treated rats when compared to control. The levels of catalase and lactate dehydrogenase were remarkably decreased in the beta -ionone treated groups compared to the positive control group. These results suggest that dietary beta -ionone has biologically relevant antioxidant activity and plays a chemopreventive role against DMBA induced mammary gland tumors.
最近，我们小组的化学预防研究表明，饮食中的β-紫罗兰酮通过抑制细胞增殖和启动细胞凋亡来抑制 7,12-二甲基苯并（a）蒽（DMBA）诱导的乳腺癌发生。在这项研究中，我们研究了饮食中不同剂量的β-紫罗兰酮对 DMBA 诱导的大鼠乳腺癌的发展和生长以及血浆抗氧化状态的化学预防作用。β-紫罗兰酮治疗组在 DMBA 给药前 2 周开始在 AIN76A 饮食中给予 9、18 和 36mmol/kg，并持续 24 周。结果表明，与阳性对照组相比，肿瘤发生率分别降低了 35.4%、68.3%和 87.8%，呈剂量依赖性。肿瘤大小呈剂量依赖性减小，每个组、每个大鼠和每个肿瘤的肿瘤重量均小于阳性对照组（P<0.05）。用饮食β-紫罗兰酮治疗的肿瘤诱导大鼠的脂质过氧化作用明显降低，而血浆抗氧化酶如谷胱甘肽过氧化物酶、谷胱甘肽还原酶、超氧化物歧化酶和非酶抗氧化剂谷胱甘肽的活性在β-紫罗兰酮治疗的大鼠中增加与对照组相比。与阳性对照组相比，β-紫罗兰酮治疗组的过氧化氢酶和乳酸脱氢酶水平显著降低。这些结果表明，饮食中的β-紫罗兰酮具有生物学相关的抗氧化活性，并在化学预防 DMBA 诱导的乳腺肿瘤方面发挥作用。
