铜（II）/铜（I）催化原位生成的α-叠氮腙的氮杂迈克尔加成/点击反应：新型吡唑啉酮三唑骨架的合成。
Copper(II)/copper(I)-catalyzed aza-Michael addition/click reaction of in situ generated alpha-azidohydrazones: synthesis of novel pyrazolone-triazole framework.
机构信息
Istituto di Chimica Organica, Università degli Studi di Urbino Carlo Bo, Via I Maggetti 24, 61029 Urbino (PU), Italy.
出版信息
Org Lett. 2010 Feb 5;12(3):468-71. doi: 10.1021/ol902642z.
PMID:20043624
Abstract
A one-pot Cu(II)-catalyzed aza-Michael addition of trimethylsilyl azide to 1,2-diaza-1,3-dienes and Cu(I)-catalyzed 1,3-dipolar cycloaddition of in situ generated alpha-azidohydrazones with alkynes is reported. This process combining two consecutive steps with recycling of the catalyst (Cu(OAc)(2).H(2)O) represents a useful protocol for the smooth synthesis of novel pyrazolone-triazole derivatives.
摘要
本文报道了一种一锅法反应
Cu(II)催化三甲基硅基叠氮化物与 1,2-二氮烯-1,3-二烯的加成反应，Cu(I)催化原位生成的α-叠氮腙与炔烃的 1,3-偶极环加成反应。该过程将两个连续步骤结合在一起，并循环使用催化剂（Cu(OAc)(2).H(2)O），为新型吡唑酮-三唑衍生物的顺利合成提供了一个有用的方案。
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