[Hemoperfusion of theophylline. An in vitro study].

The authors made 30 haemoperfusions of theophylline in vitro in a closed system, using capsules Hemasorb 800 C, Hemasorb 800 A-2 and 800 A-4. As perfusion solution they used 4 litres of aqueous solution with an osmolality of 286 mmol/kg. The theophylline concentration in solution was 282.8 +/- 5.2 mumol/l. Individual haemoperfusions lasted 5 hours. After the theophylline solution has passed across Hemasorb A-4 the concentration of the substance could be assessed at all time intervals and during the 180th minute the theophylline concentration could be detected also before entering the haemoperfusion capsule. When using Hemasorb 800 A-2, the adsorption capacity of the haemoperfusion capsule was exhausted already during the 180th minute. The assembled results suggested that the most effective theophylline haemoperfusion in vitro was obtained with Hemasorb 800 A-4 and the least effective one with Hemasorb 800 A-2. The authors recommend to use in acute intoxication with theophylline in humans haemoperfusion via Hemasorb 800 A-4.