U.S. Food & Drug Administration, Division of Pharmaceutical Analysis, 1114 Market Street, Room 1002, St. Louis, MO 63101, United States.
Int J Pharm. 2010 Mar 30;388(1-2):82-7. doi: 10.1016/j.ijpharm.2009.12.041. Epub 2010 Jan 5.
To determine aerosol deposition during the inhalation drug delivery, it is important to understand the combination of velocity and droplet size together. In this study, phase Doppler anemometry (PDA) was used to simultaneously characterize the aerosol velocity and droplet size distribution (DSD) of three nasal spray pumps filled with water. Thirteen sampling positions were located in the horizontal cross-sectional area of the nasal spray plumes at a distance of 3cm from the pump orifice. The results showed droplet velocities near the center of the spray plume were higher and more consistent than those near the edge. The pumps examined showed significant differences in their aerosol velocity at the center of the spray plume, which suggest that this metric might be used as a discriminating parameter for in vitro testing of nasal sprays. Droplet size measurements performed using PDA were compared with results from laser light scattering measurements. The ability of PDA to provide simultaneous measurements of aerosol velocity and size makes it a powerful tool for the detailed investigation of nasal spray plume characteristics.
为了确定吸入药物输送过程中的气溶胶沉积，了解速度和液滴大小的组合非常重要。在这项研究中，使用相多普勒粒子分析仪（PDA）同时表征了三种填充水的鼻喷雾剂泵的气溶胶速度和液滴尺寸分布（DSD）。在距泵孔 3cm 的位置，在鼻喷雾羽流的水平横截面区域中布置了十三个采样位置。结果表明，喷雾羽流中心附近的液滴速度比边缘附近的液滴速度更高且更一致。检查的泵在喷雾羽流中心的气溶胶速度方面表现出明显的差异，这表明该指标可能被用作鼻喷雾剂体外测试的鉴别参数。使用 PDA 进行的液滴尺寸测量结果与激光散射测量结果进行了比较。PDA 提供气溶胶速度和尺寸的同时测量的能力使其成为详细研究鼻喷雾羽流特性的强大工具。
