Bose Memorial Research Laboratory, Department of Chemistry, Government Autonomous Science College, Jabalpur, India.
Nanomedicine. 2010 Jun;6(3):453-62. doi: 10.1016/j.nano.2009.11.006. Epub 2010 Jan 4.
Swellable polymeric nanosystems have emerged as promising materials in drug release technologies. Such systems have shown potential in releasing antibiotic drugs and to do so controllably. In the present investigation poly(2-hydroxyethyl methacrylate) nanoparticles were synthesized by suspension polymerization of 2-hydroxyethyl methacrylate and characterized by various techniques such as Fourier transform-infrared spectrometry, scanning electron microscopy, particle size analysis, and surface charge measurements. The synthesized nanoparticles were swellable in water and showed promise to function as a swelling controlled-release system. The release kinetics of drug-loaded particles was studied in phosphate-buffered saline (PBS) using ciprofloxacin as a model antibacterial drug. The chemical stability of the pure and released drug was also assessed in PBS (pH 7.4), acidic (pH 1.8), and alkaline (pH 8.6) solutions. The in vitro blood compatibility of nanoparticles was also investigated in terms of hemolysis tests. The drug-loaded nanoparticles were also examined for their antibacterial and blood-compatible behaviors.
Swellable polymeric nanosystems have emerged as promising materials in drug release technologies. In this paper, the release kinetics, antimicrobial properties and in vitro "blood compatibility" is reported for a specific swellable polymeric nanosystem.
可溶胀聚合物纳米系统作为药物释放技术中的有前途的材料已经出现。此类系统在释放抗生素药物方面显示出了潜力，并且可以进行控制释放。在本研究中，通过 2-羟乙基甲基丙烯酸酯的悬浮聚合合成了聚（2-羟乙基甲基丙烯酸酯）纳米粒子，并通过傅里叶变换红外光谱、扫描电子显微镜、粒度分析和表面电荷测量等各种技术进行了表征。合成的纳米粒子在水中可溶胀，并有望作为溶胀控制释放系统发挥作用。用环丙沙星作为模型抗菌药物，在磷酸盐缓冲盐水（PBS）中研究了载药粒子的释放动力学。还在 PBS（pH7.4）、酸性（pH1.8）和碱性（pH8.6）溶液中评估了纯药物和释放药物的化学稳定性。还从溶血试验的角度研究了纳米粒子的体外血液相容性。还检查了载药纳米粒子的抗菌和血液相容性行为。
可溶胀聚合物纳米系统作为药物释放技术中的有前途的材料已经出现。在本文中，报道了一种特定的可溶胀聚合物纳米系统的释放动力学、抗菌性能和体外“血液相容性”。
