Claudin-5 过表达与浆液性卵巢腺癌的侵袭性行为相关。

Claudin-5 overexpression correlates with aggressive behavior in serous ovarian adenocarcinoma.

机构信息

Department of Obstetrics and Gynecology, 90014 University of Oulu, Finland.

出版信息

Anticancer Res. 2009 Dec;29(12):5185-9.

PMID:20044634

Abstract

BACKGROUND

Claudins are essential tight junctional proteins between adjacent epithelial, mesothelial or endothelial cells, and are responsible for the permeability of the paracellular space. The expression of claudin-5 and its correlation to ovarian cancer behavior was investigasted.

MATERIALS AND METHODS

A total of 85 serous ovarian cancer tissue samples were analyzed using immunohistochemical staining.

RESULTS

An association between claudin-5 expression and cancer grade (p=0.016) and advanced stage (p=0.022), strongest claudin-5 expression was found in advanced stage and high-grade carcinomas. An association between claudin-5 expression and cancer-specific (p=0.032) and overall survival (p=0.026) was also found. Only 25-30% of claudin-5-positive patients, but 60% of claudin-5-negative patiens were alive at the 5-years follow-up.

CONCLUSION

Increased claudin-5 expression is associated with aggressive behavior in serous ovarian adenocarcinoma.

摘要

背景

Claudin 是相邻上皮细胞、间皮细胞或内皮细胞之间的重要紧密连接蛋白，负责细胞旁空间的通透性。本研究调查了 claudin-5 的表达及其与卵巢癌行为的相关性。

材料与方法

对 85 例浆液性卵巢癌组织样本进行免疫组织化学染色分析。

结果

Claudin-5 的表达与癌症分级（p=0.016）和晚期（p=0.022）显著相关，Claudin-5 在晚期和高级别癌中表达最强。Claudin-5 的表达与癌症特异性（p=0.032）和总生存（p=0.026）也存在关联。在 5 年随访中，只有 25-30%的 Claudin-5 阳性患者存活，但 60%的 Claudin-5 阴性患者存活。