English Diana P, Santin Alessandro D
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA.
Int J Mol Sci. 2013 May 17;14(5):10412-37. doi: 10.3390/ijms140510412.
Claudins are a family of tight junction proteins regulating paracellular permeability and cell polarity with different patterns of expression in benign and malignant human tissues. There are approximately 27 members of the claudin family identified to date with varying cell and tissue-specific expression. Claudins-3, -4 and -7 represent the most highly differentially expressed claudins in ovarian cancer. While their exact role in ovarian tumors is still being elucidated, these proteins are thought to be critical for ovarian cancer cell invasion/dissemination and resistance to chemotherapy. Claudin-3 and claudin-4 are the natural receptors for the Clostridium perfringens enterotoxin (CPE), a potent cytolytic toxin. These surface proteins may therefore represent attractive targets for the detection and treatment of chemotherapy-resistant ovarian cancer and other aggressive solid tumors overexpressing claudin-3 and -4 using CPE-based theranostic agents.
闭合蛋白是一类紧密连接蛋白，可调节细胞旁通透性和细胞极性，在人体良性和恶性组织中具有不同的表达模式。迄今为止，已鉴定出约27个闭合蛋白家族成员，它们具有不同的细胞和组织特异性表达。闭合蛋白-3、-4和-7是卵巢癌中差异表达最高的闭合蛋白。虽然它们在卵巢肿瘤中的确切作用仍在阐明中，但这些蛋白被认为对卵巢癌细胞的侵袭/播散以及化疗耐药性至关重要。闭合蛋白-3和闭合蛋白-4是产气荚膜梭菌肠毒素（CPE）的天然受体，CPE是一种强效细胞溶解毒素。因此，这些表面蛋白可能是使用基于CPE的诊疗试剂检测和治疗化疗耐药性卵巢癌以及其他过表达闭合蛋白-3和-4的侵袭性实体瘤的有吸引力的靶点。
