Kettel L M, Roseff S J, Bangah M L, Burger H G, Yen S S
Department of Reproductive Medicine, School of Medicine, University of California, San Diego 92093-0802.
Clin Endocrinol (Oxf). 1991 Jan;34(1):19-23. doi: 10.1111/j.1365-2265.1991.tb01730.x.
Circulating levels of immunoreactive inhibin (ir-inhibin) and its disappearance after delivery of the placenta were determined in seven pregnant women at term. Serum oestradiol (E2) and progesterone (P4) levels were measured simultaneously and served as comparisons. Fetal contributions of ir-inhibin were assessed by determining concentrations in the umbilical artery (UA) and vein (UV). Relative changes in circulating levels of ir-inhibin, E2, and P4 were compared to levels found in nonpregnant women during the early follicular phase (EFP) and mid-luteal phase (MLP) of the normal menstrual cycle. In pregnant women, ir-inhibin levels at delivery were 15- and 3-fold higher than EFP and MLP values respectively. The disappearance of all three hormones after removal of the placenta followed a bi-exponential curve with an initial, rapid component and a second, slower component. There was a highly significant positive correlation between the disappearance curves of all three placental hormones (r = 0.97, P less than 0.0001). Concentrations of ir-inhibin in the cord blood were about half that in maternal serum and without significant difference between levels in UA and UV.
测定了7名足月孕妇循环中免疫反应性抑制素（ir-抑制素）的水平及其在胎盘娩出后的消失情况。同时测定血清雌二醇（E2）和孕酮（P4）水平作为对照。通过测定脐动脉（UA）和脐静脉（UV）中的浓度来评估胎儿对ir-抑制素的贡献。将ir-抑制素、E2和P4循环水平的相对变化与正常月经周期卵泡早期（EFP）和黄体中期（MLP）非孕妇的水平进行比较。在孕妇中，分娩时ir-抑制素水平分别比EFP和MLP值高15倍和3倍。胎盘娩出后所有三种激素的消失均呈双指数曲线，有一个初始的快速成分和第二个较慢的成分。所有三种胎盘激素的消失曲线之间存在高度显著的正相关（r = 0.97，P < 0.0001）。脐血中ir-抑制素的浓度约为母血血清中的一半，UA和UV中的水平无显著差异。
