Watanabe G, Nozaki M, Taya K, Katakai Y, Sasamoto S
Laboratory of Veterinary Physiology, Tokyo University of Agriculture and Technology, Japan.
Biol Reprod. 1990 Aug;43(2):196-201. doi: 10.1095/biolreprod43.2.196.
Serum levels of immunoreactive inhibin as well as FSH, LH, estradiol-17 beta, and progesterone were measured by RIA in four mature female Japanese monkeys (Macaca fuscata fuscata) during the breeding season and subsequent transition into the nonbreeding season. During the breeding season, each monkey showed 2-6 ovulations, which were inferred from underlying endocrine events. The concentrations of serum inhibin increased during the luteal phase, but were low during the follicular phase. Such changes in serum inhibin levels correlated positively with those in serum progesterone levels. Basal levels of serum inhibin also increased during the breeding season, decreased during transition from the breeding season, and were low during the nonbreeding season. The parallel change in serum levels of inhibin and progesterone together with the increased basal levels of serum inhibin during this period suggests that both the CL and antral follicles are sources of circulating inhibin. Decreases in serum FSH levels during the luteal phase suggest that secretion of FSH is controlled by an inhibitory action of ovarian inhibin in addition to steroid hormones.
在繁殖季节以及随后进入非繁殖季节期间，通过放射免疫分析法（RIA）测定了4只成年雌性日本猕猴（食蟹猴指名亚种）血清中免疫反应性抑制素以及促卵泡激素（FSH）、促黄体生成素（LH）、雌二醇-17β和孕酮的水平。在繁殖季节，每只猴子出现2至6次排卵，这是根据潜在的内分泌事件推断出来的。血清抑制素浓度在黄体期升高，但在卵泡期较低。血清抑制素水平的这种变化与血清孕酮水平的变化呈正相关。血清抑制素的基础水平在繁殖季节也升高，在从繁殖季节过渡期间降低，在非繁殖季节较低。在此期间，血清抑制素和孕酮水平的平行变化以及血清抑制素基础水平的升高表明，黄体和窦卵泡都是循环抑制素的来源。黄体期血清FSH水平的降低表明，除了类固醇激素外，FSH的分泌还受卵巢抑制素的抑制作用控制。
