Memorial University of Newfoundland, St. John's, NL, Canada.
Vascul Pharmacol. 2010 May-Jun;52(5-6):230-5. doi: 10.1016/j.vph.2009.12.007. Epub 2010 Jan 5.
The cardiovascular effects of interleukin 2 (IL2), were investigated in animals pretreated with indomethacin. Bolus intravenous administration of IL2 alone caused a significant reduction in cardiac output over time. Pretreatment with indomethacin significantly accentuated the reduction in cardiac output produced by IL2. The administration of IL2 or indomethacin alone or combined had no significant effects on dP/dt, heart rate or plasma troponin levels. As well, administration of either compound alone or combined had limited effects on mean circulatory filling pressure and arterial blood pressure. Injection of IL2 alone significantly increased resistance to venous return and arterial resistance at 3h post injections. Pretreatment with indomethacin caused IL2 to produce a significantly greater increase in arterial resistance and resistance to venous return. Administration of IL2 and indomethacin combined also produced significant reduction in stroke volume than IL2 or indomethacin alone. The injection of IL2 or indomethacin alone or combined had no significant impact on blood volume. Acute administration of IL2 appears to have no negative inotropic or chronotropic effects and its impact in reducing cardiac output is the result of an increase in vascular resistance. It seems that activation of prostanoids, possibly prostacyclin, has an acute beneficial effect in attenuating the initial negative effects of IL2 on cardiac output.
白细胞介素 2（IL2）的心血管作用在预先用吲哚美辛处理的动物中进行了研究。单独静脉推注 IL2 会导致心输出量随时间显著降低。吲哚美辛预处理可显著加重 IL2 引起的心输出量降低。单独给予 IL2 或吲哚美辛或两者联合均对 dP/dt、心率或血浆肌钙蛋白水平无显著影响。同样，单独给予任一化合物或联合给予这两种化合物对平均循环充盈压和动脉血压的影响也有限。单独给予 IL2 会显著增加静脉回流和动脉阻力，在注射后 3 小时达到高峰。吲哚美辛预处理可使 IL2 引起的动脉阻力和静脉回流阻力显著增加。联合给予 IL2 和吲哚美辛也比单独给予 IL2 或吲哚美辛显著降低每搏量。单独给予 IL2 或吲哚美辛或联合给予 IL2 和吲哚美辛对血容量均无显著影响。IL2 的急性给药似乎没有负性肌力或变时作用，其降低心输出量的作用是由于血管阻力增加所致。似乎前列腺素的激活，可能是前列环素，在减轻 IL2 对心输出量的初始负性影响方面具有急性有益作用。
