Leffler C W, Tyler T L, Cassin S
Circ Shock. 1978;5(3):299-310.
We examined effects of indomethacin, meclofenamate, and prostaglandin E1 on systemic arterial pressure, heart rate, cardiac output, and systemic vascular resistance of anesthetized juvenile goats in severe hemorrhagic shock. Hemorrhagic shock was characterized by low systemic arterial pressure, decreased vascular resistance, and reduction in cardiac output. In acute experiments, indomethacin (3.4 mg/kg) attenuated the systemic hypotension of hemorrhagic shock. The increase in systemic arterial pressure following treatment with indomethacin was the result of increased systemic vascular resistance. Systemic arterial pressure, heart rate, and cardiac output fell during intravenous prostaglandin E1 infusions (3 micrograms/kg/min for 5 min) in both controls and goats in shock. The effects of prostaglandin E1 were more pronounced and prolonged in goats that had undergone the hemorrhagic-shock-producing procedure followed by indomethacin than in control animals treated with indomethacin but not hemorrhaged. Not only was meclofenamate less effective than indomethacin in increasing the systemic arterial pressures of goats in this type of hemorrhagic shock, but also it attenuated the pressor effects of indomethacin. Substances synthesized via prostaglandin fatty acid cyclo-oxygenase may be involved in the systemic hypotension that is characteristic of hemorrhagic shock.
我们研究了吲哚美辛、甲氯芬那酸和前列腺素E1对严重失血性休克麻醉幼年山羊的体循环动脉压、心率、心输出量和体循环血管阻力的影响。失血性休克的特征为体循环动脉压低、血管阻力降低和心输出量减少。在急性实验中，吲哚美辛（3.4毫克/千克）减轻了失血性休克的体循环低血压。吲哚美辛治疗后体循环动脉压升高是体循环血管阻力增加的结果。在对照组和休克山羊中，静脉输注前列腺素E1（3微克/千克/分钟，持续5分钟）期间，体循环动脉压、心率和心输出量均下降。与未出血但接受吲哚美辛治疗的对照动物相比，在经历了失血性休克诱导过程并随后接受吲哚美辛治疗的山羊中，前列腺素E1的作用更明显且持续时间更长。在这种类型的失血性休克中，甲氯芬那酸在增加山羊体循环动脉压方面不仅比吲哚美辛效果差，而且还减弱了吲哚美辛的升压作用。通过前列腺素脂肪酸环氧化酶合成的物质可能参与了失血性休克特征性的体循环低血压。
