Melbourne Sleep Disorders Centre, East Melbourne, Victoria, 3002, Australia.
J Neurol Sci. 2010 Mar 15;290(1-2):146-7. doi: 10.1016/j.jns.2009.12.007. Epub 2009 Dec 31.
Autosomal dominant spinocerebellar ataxias (SCAs) are progressive neurodegenerative disorders which result in dysfunction of the neuronal systems of the spinal cord, brainstem, and cerebellum. The manifestations of daytime somnolence and abnormal sleep behavior have been described in SCA type 3 (SCA3) and SCA type 6 (SCA6), but as yet have not been described in SCA type 1 (SCA1). We report two cases of sleep disturbance, fatigue and excessive daytime somnolence in individuals with SCA1 and their progress through several therapies. These case studies are unique as they describe excessive daytime somnolence and sleep abnormalities in SCA1.
常染色体显性遗传性脊髓小脑共济失调（SCA）是一种进行性神经退行性疾病，可导致脊髓、脑干和小脑的神经元系统功能障碍。白天嗜睡和异常睡眠行为的表现已在 SCA 3 型（SCA3）和 SCA 6 型（SCA6）中描述，但尚未在 SCA 1 型（SCA1）中描述。我们报告了两例 SCA1 个体的睡眠障碍、疲劳和日间过度嗜睡，并描述了他们通过几种治疗方法的进展。这些病例研究是独特的，因为它们描述了 SCA1 中的日间过度嗜睡和睡眠异常。
