Varvat J, Thomas-Anterion C, Decousus M, Perret-Liaudet A, Laurent B
Service de neurologie, CHU Nord, 42055 Saint-Etienne cedex 02, France.
Rev Neurol (Paris). 2010 May;166(5):547-9. doi: 10.1016/j.neurol.2009.10.018. Epub 2009 Dec 31.
Among the degenerative diseases of the nervous system, Lewy body disease has the most psychiatric symptoms especially hallucinations, delusion and identification disorders.
We report a case of Lewy body disease that started with a burning mouth syndrome for three year as the only symptom before the development of a pseudo-psychiatric syndrome (melancholy and Capgras). None of the usual cardinal criteria were present. MRI, cerebrospinal fluid, and DAT scan findings enabled the diagnosis.
The dopaminergic hypothesis put forward in some cases of burning mouth syndrome might explain this symptom in Lewy body disease.
在神经系统退行性疾病中,路易体病的精神症状最为突出,尤其是幻觉、妄想和身份识别障碍。
我们报告一例路易体病,在出现假性精神综合征(忧郁和卡普格拉综合征)之前,以灼口综合征为唯一症状持续了三年。没有出现任何常见的主要标准症状。MRI、脑脊液和多巴胺转运体(DAT)扫描结果得以确诊。
在某些灼口综合征病例中提出的多巴胺能假说可能解释路易体病中的这种症状。