Department of Neurology, Heinrich-Heine-Universität Düsseldorf, 40225 Düsseldorf, Germany.
Trends Neurosci. 2010 Mar;33(3):140-52. doi: 10.1016/j.tins.2009.12.002. Epub 2010 Jan 4.
Multiple sclerosis (MS), an incurable but manageable disorder, is characterized by chronic inflammatory demyelination and neurodegeneration in the central nervous system. Although the primary cause of this often devastating disease remains elusive, major therapeutic advances have occurred during the past two decades. Here, we present a review of current immunomodulatory treatments and outline upcoming therapy approaches, including biologics and oral alternatives that might have equivalent or superior efficacy and/or enhanced tolerability compared with available treatments, and discuss the scientific rationale and expected benefits and risks for these compounds. We also speculate about alternatives beyond immune-directed approaches, review novel insights into the neurobiological consequences of sustained brain inflammation and evaluate future perspectives for neuroprotective and neuroregenerative treatment strategies for MS.
多发性硬化症（MS）是一种无法治愈但可治疗的疾病，其特征是中枢神经系统的慢性炎症性脱髓鞘和神经退行性变。尽管这种经常导致残疾的疾病的主要原因仍不明确，但在过去二十年中已经取得了重大的治疗进展。在这里，我们对当前的免疫调节治疗进行了综述，并概述了即将出现的治疗方法，包括生物制剂和口服替代品，它们可能具有与现有治疗方法等效或更高的疗效和/或增强的耐受性，并讨论了这些化合物的科学原理以及预期的益处和风险。我们还推测了超越免疫靶向方法的替代方法，综述了持续脑炎症的神经生物学后果的新见解，并评估了多发性硬化症的神经保护和神经再生治疗策略的未来前景。
