Ursino M
Engineering University, Bologna, Italy.
Crit Rev Biomed Eng. 1991;18(4):255-88.
The main aspects of cerebral blood flow regulation are analyzed in the present work. Particular emphasis is given to the biophysical aspects of the cerebral circulation and to problems related with mathematical modeling. Throughout the present work a systemic approach is used, i.e., the intracranial circulation is regarded as a complex system, the behavior of which derives from the interaction and superimposition of several concomitant effects. A brief historical review of the major experimental results on cerebrovascular regulation is presented. Subsequently, the functional structure of the cerebrovascular bed is analyzed in detail and the major feedback regulatory mechanisms, which are now assumed to work on the cerebral circulation (that is, the chemical, the myogenic and the neurogenic ones) are separately examined, according to recently published literature. Mathematical models able to describe all these phenomena are presented and their advantages, limitations, and possible role in physiological investigation discussed. Finally, attention is focused on the major problems which still deserve further studies and on possible lines for future investigations.
本文分析了脑血流调节的主要方面。特别强调了脑循环的生物物理方面以及与数学建模相关的问题。在整个本文中，采用了一种系统的方法，即颅内循环被视为一个复杂系统，其行为源于几种伴随效应的相互作用和叠加。本文简要回顾了脑血管调节的主要实验结果。随后，详细分析了脑血管床的功能结构，并根据最近发表的文献分别研究了目前认为作用于脑循环的主要反馈调节机制（即化学、肌源性和神经源性机制）。本文介绍了能够描述所有这些现象的数学模型，并讨论了它们的优点、局限性以及在生理学研究中的可能作用。最后，关注的重点是仍值得进一步研究的主要问题以及未来研究的可能方向。
