Olivera-González S, de Escalante-Yangüela B, Velilla-Soriano C, Amores-Arriaga B, Martín-Fortea P, Navarro-Aguilar M E
Servicio de Medicina Interna, Hospital Clínico Universitario Lozano Blesa, Zaragoza, España.
Med Intensiva. 2010 Oct;34(7):483-7. doi: 10.1016/j.medin.2009.10.006. Epub 2010 Jan 4.
Metformin is an oral biguanide widely used in the management of patients with type 2 diabetes. It produces non-specific gastrointestinal symptoms in 10-30% of the patients. Lactic acidosis is the most serious side effect, so it must not be administered to patients with renal, liver, or heart insufficiency. Only a few cases of hepatotoxicity due to this drug have been documented. We report the case of a patient with type 2 diabetes mellitus and recent use of metformin who developed serious liver injury, followed by a favorable evolution.
二甲双胍是一种口服双胍类药物，广泛用于2型糖尿病患者的治疗。10%至30%的患者会出现非特异性胃肠道症状。乳酸酸中毒是最严重的副作用，因此不得用于肾功能、肝功能或心功能不全的患者。仅有少数该药物导致肝毒性的病例有记录。我们报告了一例2型糖尿病患者的病例，该患者近期使用二甲双胍后出现严重肝损伤，随后病情好转。
