Zheng Lin
Division of Hospital Medicine, Department of Medicine, Cooper University Hospital, Cooper Medical School of Rowan University, Camden, NJ.
Am J Ther. 2016 Jan-Feb;23(1):e315-7. doi: 10.1097/MJT.0000000000000007.
Metformin is an oral hypoglycemic agent that is commonly used in the treatment of type 2 diabetes mellitus. Although metformin-associated gastrointestinal upset and metabolic acidosis is widely recognized side effect of this drug, metformin-induced liver injury has been rarely reported in the literature. In most cases reported, metformin-induced liver injury was associated with concomitant intake of other hepatotoxic drugs. Here, we report a case of a 70-year-old white woman who suffered metformin-induced liver injury 5 weeks after starting on this medication, and she was not on any other hepatotoxic agent. With increasing prescription of metformin, this case deserves particular attention for this rare but important side effect.
二甲双胍是一种常用于治疗2型糖尿病的口服降糖药。尽管二甲双胍相关的胃肠道不适和代谢性酸中毒是该药物广为人知的副作用，但二甲双胍引起的肝损伤在文献中鲜有报道。在大多数已报道的病例中，二甲双胍引起的肝损伤与同时服用其他肝毒性药物有关。在此，我们报告一例70岁白人女性病例，该患者在开始服用此药5周后出现二甲双胍引起的肝损伤，且未服用任何其他肝毒性药物。随着二甲双胍处方量的增加，这种罕见但重要的副作用值得特别关注。
