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Cholesterol synthesis in freshly isolated human leukocytes.

作者信息

Tarugi P, Romoli V, Crovetti F, Calandra S

出版信息

Experientia. 1977 Nov 15;33(11):1426-7. doi: 10.1007/BF01918783.

DOI:10.1007/BF01918783
PMID:200457
Abstract

Cholesterol synthesis has been studied in human leukocytes shortly after the isolation from healthy subjects. Not delipidated human serum reduced the cholesterol synthesis when added to the incubation medium. A similar effect was obtained when the leukocytes were incubated in the presence of physiological concentrations of low density lipoproteins.

摘要

相似文献

1
Cholesterol synthesis in freshly isolated human leukocytes.
Experientia. 1977 Nov 15;33(11):1426-7. doi: 10.1007/BF01918783.
2
Cholesterol synthesis in cultured human peripheral lymphocytes. Influence of LDL, HDL, cholesterol/phosphatidylcholine liposomes and complete serum.培养的人外周血淋巴细胞中的胆固醇合成。低密度脂蛋白、高密度脂蛋白、胆固醇/磷脂酰胆碱脂质体和完全血清的影响。
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3
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J Lipid Res. 1979 Mar;20(3):413-6.
4
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Arch Int Physiol Biochim. 1983 Sep;91(3):179-85.
6
Lipoprotein metabolism by rat hepatomas. Studies on the etiology of defective dietary feedback inhibition of cholesterol synthesis.大鼠肝癌的脂蛋白代谢。关于胆固醇合成的膳食反馈抑制缺陷病因学的研究。
J Clin Invest. 1984 Jul;74(1):173-84. doi: 10.1172/JCI111399.
7
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Am J Obstet Gynecol. 1984 Nov 1;150(5 Pt 1):551-7. doi: 10.1016/s0002-9378(84)90438-1.
8
Melatonin inhibits LDL receptor activity and cholesterol synthesis in freshly isolated human mononuclear leukocytes.
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Regulation of low density lipoprotein receptor activity in freshly isolated human lymphocytes.新鲜分离的人淋巴细胞中低密度脂蛋白受体活性的调节
J Clin Invest. 1976 Dec;58(6):1465-74. doi: 10.1172/JCI108603.
10
Effects of bezafibrate on biosynthesis of cholesterol and on degradation of native and acetylated low-density lipoproteins in incubated human monocytes.苯扎贝特对培养的人单核细胞中胆固醇生物合成以及天然和乙酰化低密度脂蛋白降解的影响。
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本文引用的文献

1
Leukocyte preparations from human blood: evaluation of their morphologic and metabolic state.人血白细胞制剂：其形态和代谢状态的评估
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Studies on the fibrinogen, dextran and phytohemagglutinin methods of isolating leukocytes.关于纤维蛋白原、右旋糖酐和植物血凝素分离白细胞方法的研究。
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Cholesterol synthesis by cultured fibroblasts: decreased feedback inhibition in familial hypercholesterolemia.培养的成纤维细胞的胆固醇合成：家族性高胆固醇血症中反馈抑制作用减弱。
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Familial hypercholesterolemia: defective binding of lipoproteins to cultured fibroblasts associated with impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity.家族性高胆固醇血症：脂蛋白与培养的成纤维细胞结合缺陷，与3-羟基-3-甲基戊二酰辅酶A还原酶活性调节受损有关。
Proc Natl Acad Sci U S A. 1974 Mar;71(3):788-92. doi: 10.1073/pnas.71.3.788.
6
Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in cultured human fibroblasts. Comparison of cells from a normal subject and from a patient with homozygous familial hypercholesterolemia.培养的人成纤维细胞中3-羟基-3-甲基戊二酰辅酶A还原酶活性的调节。正常受试者与纯合子家族性高胆固醇血症患者细胞的比较。
J Biol Chem. 1974 Feb 10;249(3):789-96.
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Regulation of cholesterol biosynthesis in rat liver after the administration of N-2-fluorenylacetamide.给予N-2-芴基乙酰胺后大鼠肝脏中胆固醇生物合成的调节
Lab Invest. 1973 Jun;28(6):723-7.
8
In vitro effects of serum proteins and lipids on lipid synthesis in human skin fibroblasts and leukocytes grown in culture.血清蛋白和脂质对体外培养的人皮肤成纤维细胞和白细胞脂质合成的影响。
Biochim Biophys Acta. 1972 Mar 23;260(3):413-23. doi: 10.1016/0005-2760(72)90056-2.
9
Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and the esterification of cholesterol in human long term lymphoid cell lines.人长期淋巴细胞系中3-羟基-3-甲基戊二酰辅酶A还原酶活性及胆固醇酯化作用的调节
Biochemistry. 1976 Feb 10;15(3):521-8. doi: 10.1021/bi00648a011.
10
Cholesterol, 7-ketocholesterol and 25-hydroxycholesterol uptake studies and effect on 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity in human fibroblasts.胆固醇、7-酮胆固醇和25-羟基胆固醇摄取研究及其对人成纤维细胞中3-羟基-3-甲基戊二酰辅酶A还原酶活性的影响。
Biochim Biophys Acta. 1975 Jul 22;398(1):10-7. doi: 10.1016/0005-2760(75)90165-4.