Chen Annie V, Bagley Rodney S, Talcott Patricia A
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, 100 Grimes Way, Pullman, Washington 99164, USA.
J Am Anim Hosp Assoc. 2010 Jan-Feb;46(1):43-7. doi: 10.5326/0460043.
A 2-year-old, intact male Weimaraner was evaluated for episodic extensor rigidity and a stiff gait of 24 hours' duration. Percussion of the proximal appendicular muscles with a reflex hammer resulted in formation of dimples consistent with myotonia. Electromyography identified myotonic potentials. Residues of 2,4-dichlorophenoxyacetic acid (2,4-D) were detected in both serum and urine. The dog was treated with intravenous fluid therapy for 36 hours, and clinical signs improved dramatically. Toxicosis with 2,4-D should be considered a differential for acquired myotonia in dogs with or without systemic signs. Exposed dogs with only clinical signs of myotonia can have good clinical outcomes. A confirmed clinical case of 2,4-D toxicosis in the dog has not previously been reported.
对一只2岁未绝育的雄性魏玛犬进行了评估，该犬出现发作性伸肌强直和持续24小时的僵硬步态。用反射锤叩击近端附属肌，出现与肌强直一致的凹陷。肌电图检查发现了肌强直电位。在血清和尿液中均检测到2,4-二氯苯氧乙酸（2,4-D）残留。对该犬进行了36小时的静脉补液治疗，临床症状显著改善。2,4-D中毒应被视为有或无全身症状的犬获得性肌强直的鉴别诊断。仅出现肌强直临床症状的暴露犬可能有良好的临床预后。此前尚未有犬2,4-D中毒确诊临床病例的报道。
