Harrington M L, Moore M P, Talcott P A, Bagley R S, Sandmeier P
Department of Clinical Sciences, Washington State University, College of Veterinary Medicine, Pullman 99164-6610, USA.
J Am Vet Med Assoc. 1996 Dec 15;209(12):2085-7.
An 8-year-old 38-kg spayed female Golden Retriever was admitted for vomiting, signs of abdominal pain on palpation, ataxia, anorexia, and generalized weakness of 2 days' duration. Ten hours prior to onset of clinical signs, the dog was found standing in and drinking from large pools of an accidentally spilled herbicide that contained an octanoic acid ester of bromoxynil (3,5-dibromo-4-hydroxybenzonitrile) and an isooctyl ester of (2-methyl-4-chloro) phenoxyacetic acid (MCPA). Appendicular muscles were firm on palpation and persistent muscle contraction (myotonia > 1 minute duration) was found on muscle percussion, using a reflex hammer. Electrical activity indicative of myotonia was identified on electromyographic evaluation. With supportive treatment, the dog eventually recovered from suspected MCPA toxicosis. Although rare, MCPA toxicosis should be considered as a cause of acquired myotonia in dogs.
一只8岁、体重38千克的绝育雌性金毛猎犬因呕吐、触诊时有腹痛迹象、共济失调、厌食以及持续2天的全身无力而入院。在临床症状出现前10小时，发现这只狗站在意外洒出的一大滩除草剂中并饮用了该除草剂，该除草剂含有溴苯腈辛酸酯（3,5 - 二溴 - 4 - 羟基苯腈）和（2 - 甲基 - 4 - 氯）苯氧基乙酸异辛酯（MCPA）。触诊时四肢肌肉坚实，使用反射锤进行肌肉叩诊时发现持续性肌肉收缩（肌强直持续时间>1分钟）。在肌电图评估中发现了指示肌强直的电活动。经过支持性治疗，这只狗最终从疑似MCPA中毒中康复。尽管罕见，但MCPA中毒应被视为犬类获得性肌强直的一个病因。
