Kobayashi Ryosuke, Tanaka Fumihiko, Asai Atsusi, Kagawa Yumiko, Ikeda Teruo, Shirota Kinji
Research Institute of Biosciences, Azabu University, 1-17-71 Fuchinobe, Sagamihara, Kanagawa 229-8501, Japan.
J Vet Med Sci. 2009 Dec;71(12):1669-72. doi: 10.1292/jvms.001669.
Cytological, histopathological and immunohistochemical examinations were carried out on a presumed 10-year-old Japanese cat showing vomiting and emaciation. On cytologic examination of the mass of the upper abdominal cavity, many yeast-like organisms were detected in the macrophages. At necropsy, the upper part of colon was markedly dilated with a thickened wall. The lung did not show significant changes. Histologically, severe necrotic and granulomatous lesions were observed in the colon. In the colonic lesion, the cytoplasm of the macrophages contained yeast-like organisms with irregularly shaped dots, and the cell walls of these organisms were stained black by Grocott-Gomori methenamine-silver stain. Immunohistochemically, they were found to be positive for anti-histoplasma yeast antibody. This is the first report of feline histoplasmosis in Japan.
对一只疑似10岁的日本猫进行了细胞学、组织病理学和免疫组织化学检查，该猫出现呕吐和消瘦症状。对上腹腔肿块进行细胞学检查时，在巨噬细胞中检测到许多酵母样生物体。尸检时，结肠上部明显扩张，壁增厚。肺部未显示明显变化。组织学检查发现，结肠出现严重的坏死和肉芽肿性病变。在结肠病变中，巨噬细胞的细胞质中含有带有不规则点状的酵母样生物体，这些生物体的细胞壁经Grocott-Gomori六胺银染色后呈黑色。免疫组织化学检查发现，它们对抗组织胞浆菌酵母抗体呈阳性。这是日本首例猫组织胞浆菌病报告。
