Department of Surgery, New York Medical College, Valhalla, New York, USA.
Int J Med Sci. 2009 Dec 6;7(1):29-35. doi: 10.7150/ijms.7.29.
Oxidative stress plays a major role in the pathogenesis of both types of diabetes mellitus and cardiovascular diseases including hypertension. The low levels of antioxidants accompanied by raised levels of markers of free radical damage play a major role in delaying wound healing. Ultra-low microcurrent presumably has an antioxidant effect, and it was shown to accelerate wound healing. The purpose of the study is to investigate the efficacy of ultra-low microcurrent delivered by the Electro Pressure Regeneration Therapy (EPRT) device (EPRT Technologies-USA, Simi Valley, CA) in the management of diabetes, hypertension and chronic wounds. The EPRT device is an electrical device that sends a pulsating stream of electrons in a relatively low concentration throughout the body. The device is noninvasive and delivers electrical currents that mimic the endogenous electric energy of the human body. It is a rechargeable battery-operated device that delivers a direct current (maximum of 3 milliAmperes) of one polarity for 11.5 minutes, which then switched to the opposite polarity for another 11.5 minutes. The resulting cycle time is approximately 23min or 0.000732 Hz and delivers a square wave bipolar current with a voltage ranging from 5V up to a maximum of 40 V. The device produces a current range of 3 mA down to 100 nA. Twelve patients with long standing diabetes, hypertension and unhealed wounds were treated with EPRT. The patients were treated approximately for 3.5 h/day/5 days a week. Assessment of ulcer was based on scale used by National Pressure Ulcer Advisory Panel Consensus Development Conference. Patients were followed-up with daily measurement of blood pressure and blood glucose level, and their requirement for medications was recorded. Treatment continued from 2-4 months according to their response. Results showed that diabetes mellitus and hypertension were well controlled after using this device, and their wounds were markedly healed (30-100%). The patients either reduced their medication or completely stopped after the course of treatment. No side effects were reported. The mechanism of action was discussed.
氧化应激在 1 型和 2 型糖尿病以及包括高血压在内的心血管疾病的发病机制中起着重要作用。抗氧化剂水平降低，自由基损伤标志物水平升高，这在很大程度上导致了伤口愈合的延迟。超低频微电流可能具有抗氧化作用，并且已被证明可以加速伤口愈合。本研究旨在探讨 Electro Pressure Regeneration Therapy（EPRT）设备（EPRT Technologies-USA，Simi Valley，CA）产生的超低频微电流在糖尿病、高血压和慢性伤口管理中的疗效。EPRT 设备是一种向全身发送浓度相对较低的电子脉冲流的电气设备。该设备是非侵入性的，可提供模拟人体内源性电能的电流。它是一种可充电电池供电的设备，可提供 1 个极性的直流电（最大 3 毫安）持续 11.5 分钟，然后切换到另一个极性再持续 11.5 分钟。因此一个周期的时间约为 23 分钟或 0.000732Hz，并以 5V 至 40V 的电压范围提供方波双极电流。该设备产生的电流范围为 3mA 至 100nA。12 例患有长期糖尿病、高血压和未愈合伤口的患者接受了 EPRT 治疗。患者每天接受治疗约 3.5 小时/5 天/周。溃疡评估基于国家压疮咨询小组共识发展会议使用的量表。通过每天测量血压和血糖水平并记录他们的药物需求来对患者进行随访。根据他们的反应，治疗持续 2-4 个月。结果表明，使用该设备后糖尿病和高血压得到了很好的控制，他们的伤口明显愈合（30-100%）。治疗结束后，患者要么减少用药，要么完全停药。未报告任何副作用。讨论了作用机制。
