青少年2型糖尿病、多囊卵巢综合征与胰岛素抵抗综合征：它们是一座巨大的冰山吗？
Type 2 diabetes, polycystic ovary syndrome and the insulin resistance syndrome in adolescents: Are they one big iceberg?
作者信息
Dean Heather J, Sellers Elizabeth Ac
机构信息
Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba.
出版信息
Paediatr Child Health. 2002 May;7(5):333-6.
Obesity in children may cause overt clinical disease in childhood. The complex endocrine and metabolic changes of obesity and insulin resistance in adolescents result in hyperinsulinemia, dyslipidemia, hypertension, steatohepatitis, glucose intolerance, type 2 diabetes, acanthosis nigricans and ovarian hyperandrogenemia, commonly known as polycystic ovarian syndrome (PCOS). Type 2 diabetes and PCOS in adolescents are new endocrine diseases in this age group that require unique approaches to diagnosis and treatment. The direct correlation between duration of disease and control of the disease, and subsequent long term complications of these two diseases, predict serious morbidity in young adult life for the affected adolescents. Pediatricians have an important role in the prevention, diagnosis and treatment of obesity, insulin resistance syndrome, type 2 diabetes and PCOS.
儿童肥胖可能在童年期引发明显的临床疾病。青少年肥胖和胰岛素抵抗的复杂内分泌及代谢变化会导致高胰岛素血症、血脂异常、高血压、脂肪性肝炎、葡萄糖不耐受、2型糖尿病、黑棘皮病以及卵巢雄激素过多症，即通常所说的多囊卵巢综合征（PCOS）。青少年中的2型糖尿病和PCOS是该年龄组新出现的内分泌疾病，需要采用独特的诊断和治疗方法。疾病持续时间与疾病控制之间的直接关联，以及这两种疾病随后的长期并发症，预示着受影响的青少年在成年早期会出现严重的发病情况。儿科医生在肥胖、胰岛素抵抗综合征、2型糖尿病和PCOS的预防、诊断及治疗中发挥着重要作用。
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