Reproductive Medicine Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Department of Obstetrics and Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Front Endocrinol (Lausanne). 2021 Jan 7;11:537809. doi: 10.3389/fendo.2020.537809. eCollection 2020.
Levels of circulating adipokines in nonobese polycystic ovary syndrome (PCOS) patients have been reported in many studies. However, the results are inconsistent. The aim of this meta-analysis is to assess whether the levels of circulating adipokines are changed in nonobese PCOS relative to nonobese healthy controls. To identify eligible studies, a literature research was performed in the PubMed, Embase, and Web of Science databases without restricting by region, journal, or language. A total of 81 studies met the eligibility criteria. The meta-analysis showed that the circulating level of adiponectin (standardized mean difference [SMD]: -0.95; 95% CI: -1.36 to -0.53) was significantly decreased in nonobese PCOS patients. In contrast, the circulating levels of chemerin (SMD: 1.13; 95% CI: 0.08 to 2.18), leptin (SMD: 0.47; 95% CI: 0.13 to 0.81), resistin (SMD: 0.45; 95% CI: 0.03 to 0.88), and visfatin (SMD: 1.38; 95% CI: 0.68 to 2.09) were significantly increased in nonobese PCOS patients. There were no significant changes in the circulating levels of apelin (SMD: 0.32; 95% CI: -1.34 to 1.99), irisin (SMD: 1.01; 95% CI: -0.68 to 2.70), omentin (SMD: -0.37; 95% CI: -1.05 to 0.31), or vaspin (SMD: 0.09; 95% CI: -0.14 to 0.32). Thus, scientific evidence suggests that the circulating adipokine levels are altered in nonobese PCOS patients compared to nonobese healthy controls. Therefore, independent of the degree of obesity, dysregulated circulating adipokine levels might play important roles in the occurrence and development of PCOS.
许多研究报告了非肥胖型多囊卵巢综合征（PCOS）患者循环脂肪因子的水平。然而，结果并不一致。本荟萃分析的目的是评估非肥胖型 PCOS 患者的循环脂肪因子水平是否与非肥胖型健康对照者不同。为了确定合格的研究，在 PubMed、Embase 和 Web of Science 数据库中进行了文献检索，没有按地区、期刊或语言进行限制。共有 81 项研究符合入选标准。荟萃分析显示，非肥胖型 PCOS 患者的循环脂联素水平明显降低（标准化均数差 [SMD]：-0.95；95%置信区间：-1.36 至-0.53）。相比之下，循环 chemerin（SMD：1.13；95%置信区间：0.08 至 2.18）、瘦素（SMD：0.47；95%置信区间：0.13 至 0.81）、抵抗素（SMD：0.45；95%置信区间：0.03 至 0.88）和 visfatin（SMD：1.38；95%置信区间：0.68 至 2.09）的水平显著升高。循环 apelin（SMD：0.32；95%置信区间：-1.34 至 1.99）、irisin（SMD：1.01；95%置信区间：-0.68 至 2.70）、网膜素（SMD：-0.37；95%置信区间：-1.05 至 0.31）或 vaspin（SMD：0.09；95%置信区间：-0.14 至 0.32）的水平没有显著变化。因此，科学证据表明，与非肥胖型健康对照者相比，非肥胖型 PCOS 患者的循环脂肪因子水平发生了改变。因此，无论肥胖程度如何，失调的循环脂肪因子水平可能在 PCOS 的发生和发展中发挥重要作用。
